Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer
BACKGROUND: It is hypothesized that BRAF mutant cancers represent a discrete subset of
metastatic colorectal cancer (CRC) defined by poorer survival. This study investigates …
metastatic colorectal cancer (CRC) defined by poorer survival. This study investigates …
[HTML][HTML] BRAF mutations, microsatellite instability status and cyclin D1 expression predict metastatic colorectal patients' outcome
Z Saridaki, D Papadatos-Pastos, M Tzardi… - British journal of …, 2010 - nature.com
Background: The significance of BRAF mutations, microsatelite instability (MSI) status and
cyclin D1 expression in patients with metastatic colorectal cancer (mCRC) was evaluated …
cyclin D1 expression in patients with metastatic colorectal cancer (mCRC) was evaluated …
BRAF mutations in colorectal cancer are associated with distinct clinical characteristics and worse prognosis
MF Kalady, KL DeJulius, JA Sanchez… - Diseases of the colon …, 2012 - journals.lww.com
BACKGROUND: Colorectal cancer is a heterogeneous disease with multiple underlying
genetic mutations causing different clinical phenotypes. Mutation in the BRAF oncogene is a …
genetic mutations causing different clinical phenotypes. Mutation in the BRAF oncogene is a …
The association between mutations in BRAF and colorectal cancer–specific survival depends on microsatellite status and tumor stage
H Bläker, E Alwers, A Arnold, E Herpel… - Clinical …, 2019 - Elsevier
Background & Aims Colorectal tumors with mutations in BRAF and microsatellite stability
(MSS) have been associated with adverse outcomes of patients. Combined tests for …
(MSS) have been associated with adverse outcomes of patients. Combined tests for …
BRAF Mutation Status and Survival after Colorectal Cancer Diagnosis According to Patient and Tumor Characteristics
AI Phipps, DD Buchanan, KW Makar… - … , biomarkers & prevention, 2012 - AACR
Background: BRAF mutations in colorectal cancer (CRC) are disproportionately observed in
tumors exhibiting microsatellite instability (MSI) and are associated with other prognostic …
tumors exhibiting microsatellite instability (MSI) and are associated with other prognostic …
Progression-free survival remains poor over sequential lines of systemic therapy in patients with BRAF-mutated colorectal cancer
Background BRAF mutations occur in 5% to 10% of metastatic colorectal cancers and are
biomarkers associated with a poor prognosis. However, the outcomes with standard …
biomarkers associated with a poor prognosis. However, the outcomes with standard …
BRAF mutation predicts for poor outcomes after metastasectomy in patients with metastatic colorectal cancer
BACKGROUND BRAF mutations occur in 5% to 11% of patients with metastatic colorectal
cancer (mCRC) and have been associated with poor prognosis. The current study was …
cancer (mCRC) and have been associated with poor prognosis. The current study was …
[HTML][HTML] BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability …
W Qi Li, K Kawakami, A Ruszkiewicz, G Bennett… - Molecular cancer, 2006 - Springer
Background BRAF is a member of RAF family of serine/threonine kinases and mediates
cellular responses to growth signals through the RAS-RAF-MAP kinase pathway. Activating …
cellular responses to growth signals through the RAS-RAF-MAP kinase pathway. Activating …
Non-V600BRAF Mutations Define a Clinically Distinct Molecular Subtype of Metastatic Colorectal Cancer
JC Jones, LA Renfro, HO Al-Shamsi… - Journal of Clinical …, 2017 - ascopubs.org
Purpose Molecular diagnostic testing has become an integral part of the evaluation of
patients with metastatic colorectal cancer (CRC). Expanded mutational testing, such as next …
patients with metastatic colorectal cancer (CRC). Expanded mutational testing, such as next …
[HTML][HTML] BRAF codons 594 and 596 mutations identify a new molecular subtype of metastatic colorectal cancer at favorable prognosis
Background While the negative prognostic role of BRAF V600E mutation in metastatic
colorectal cancer (mCRC) is well established, the impact of BRAF codons 594 and 596 …
colorectal cancer (mCRC) is well established, the impact of BRAF codons 594 and 596 …
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