Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Meta-Analyses of Glucose and Insulin-related traits … - Nature …, 2012 - nature.com
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes
(T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including …
(T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including …
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Genome-wide association (GWA) studies have identified multiple loci at which common
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …
Genome-wide association studies in type 2 diabetes
MI McCarthy, E Zeggini - Current diabetes reports, 2009 - Springer
Despite numerous candidate gene and linkage studies, the field of type 2 diabetes (T2D)
genetics had until recently succeeded in identifying few genuine disease-susceptibility loci …
genetics had until recently succeeded in identifying few genuine disease-susceptibility loci …
[HTML][HTML] Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes
Abstract Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a
meta-analysis of genome-wide association studies (GWAS) with~ 16 million genetic variants …
meta-analysis of genome-wide association studies (GWAS) with~ 16 million genetic variants …
Genome-wide association studies and type 2 diabetes
In recent years, the search for genetic determinants of type 2 diabetes (T2D) has changed
dramatically. Although linkage and small-scale candidate gene studies were highly …
dramatically. Although linkage and small-scale candidate gene studies were highly …
Type 2 diabetes: genetic data sharing to advance complex disease research
J Flannick, JC Florez - Nature Reviews Genetics, 2016 - nature.com
As with other complex diseases, unbiased association studies followed by physiological and
experimental characterization have for years formed a paradigm for identifying genes or …
experimental characterization have for years formed a paradigm for identifying genes or …
Genetic architecture of type 2 diabetes
K Hara, N Shojima, J Hosoe, T Kadowaki - Biochemical and biophysical …, 2014 - Elsevier
Genome-wide association studies (GWAS) have identified over 70 loci associated with type
2 diabetes (T2D). Most genetic variants associated with T2D are common variants with …
2 diabetes (T2D). Most genetic variants associated with T2D are common variants with …
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
By combining genome-wide association data from 8,130 individuals with type 2 diabetes
(T2D) and 38,987 controls of European descent and following up previously unidentified …
(T2D) and 38,987 controls of European descent and following up previously unidentified …
Genomic insights into the causes of type 2 diabetes
C Langenberg, LA Lotta - The Lancet, 2018 - thelancet.com
Genome-wide association studies have implicated around 250 genomic regions in
predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for …
predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for …
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
DIAbetes Genetics Replication And Meta-analysis … - Nature …, 2014 - nature.com
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS) …
aggregated published meta-analyses of genome-wide association studies (GWAS) …