Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
DIAbetes Genetics Replication And Meta-analysis … - Nature …, 2014 - nature.com
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS) …
aggregated published meta-analyses of genome-wide association studies (GWAS) …
[HTML][HTML] Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
N Genet - Nat Genet, 2014 - ncbi.nlm.nih.gov
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS) …
aggregated published meta-analyses of genome-wide association studies (GWAS) …
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
A Mahajan, CN Spracklen, W Zhang, MCY Ng… - Nature …, 2022 - nature.com
We assembled an ancestrally diverse collection of genome-wide association studies
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
Genomic insights into the causes of type 2 diabetes
C Langenberg, LA Lotta - The Lancet, 2018 - thelancet.com
Genome-wide association studies have implicated around 250 genomic regions in
predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for …
predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for …
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However,
little is known about the genetic risk in African Americans despite the recent identification of …
little is known about the genetic risk in African Americans despite the recent identification of …
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Genome-wide association (GWA) studies have identified multiple loci at which common
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …
Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
We assembled an ancestrally diverse collection of genome-wide association studies of type
2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent) …
2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent) …
Genome-wide association scans for Type 2 diabetes: new insights into biology and therapy
MI McCarthy, E Zeggini - Trends in pharmacological sciences, 2007 - cell.com
Type 2 diabetes is a complex, multifactorial disease, for which genetic and environmental
factors jointly determine susceptibility. Disentangling the genetic aetiology of Type 2 …
factors jointly determine susceptibility. Disentangling the genetic aetiology of Type 2 …
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
JS Kooner, D Saleheen, X Sim, J Sehmi, W Zhang… - Nature …, 2011 - nature.com
We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …
Recessive genome-wide meta-analysis illuminates genetic architecture of type 2 diabetes
MJ O'Connor, P Schroeder, A Huerta-Chagoya… - Diabetes, 2022 - Am Diabetes Assoc
Most genome-wide association studies (GWAS) of complex traits are performed using
models with additive allelic effects. Hundreds of loci associated with type 2 diabetes have …
models with additive allelic effects. Hundreds of loci associated with type 2 diabetes have …
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