[HTML][HTML] Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression
M Clerici, V Paciotti, V Baldo, M Romano… - The EMBO …, 2001 - embopress.org
The evolutionarily conserved yeast Mec1 and Tel1 protein kinases, as well as the Mec1-
interacting protein Ddc2, are involved in the DNA damage checkpoint response. We show …
interacting protein Ddc2, are involved in the DNA damage checkpoint response. We show …
Four pillars of the S-phase checkpoint
L Zou - Genes & development, 2013 - genesdev.cshlp.org
The yeast Mec1 kinase is a key regulator of the DNA damage response (DDR). In this issue
of Genes & Development, Kumar and Burgers (pp. 313–321) report that Ddc1, Dpb11, and …
of Genes & Development, Kumar and Burgers (pp. 313–321) report that Ddc1, Dpb11, and …
Association of Rad9 with double-strand breaks through a Mec1-dependent mechanism
T Naiki, T Wakayama, D Nakada… - … and cellular biology, 2004 - Taylor & Francis
Rad9 is required for the activation of DNA damage checkpoint pathways in budding yeast.
Rad9 is phosphorylated after DNA damage in a Mec1-and Tel1-dependent manner and …
Rad9 is phosphorylated after DNA damage in a Mec1-and Tel1-dependent manner and …
A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1
M Clerici, V Baldo, D Mantiero… - … and cellular biology, 2004 - Taylor & Francis
In Saccharomyces cerevisiae, Mec1/ATR plays a primary role in sensing and transducing
checkpoint signals in response to different types of DNA lesions, while the role of the …
checkpoint signals in response to different types of DNA lesions, while the role of the …
Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double‐strand breaks
D Mantiero, M Clerici, G Lucchini, MP Longhese - EMBO reports, 2007 - embopress.org
The main responder to DNA double‐strand breaks (DSBs) in mammals is ataxia
telangiectasia mutated (ATM), whereas DSB‐induced checkpoint activation in budding yeast …
telangiectasia mutated (ATM), whereas DSB‐induced checkpoint activation in budding yeast …
[HTML][HTML] Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p
V Paciotti, G Lucchini, P Plevani, MP Longhese - The EMBO journal, 1998 - embopress.org
Checkpoints prevent DNA replication or nuclear division when chromosomes are damaged.
The Saccharomyces cerevisiae DDC1 gene belongs to the RAD17, MEC3 and RAD24 …
The Saccharomyces cerevisiae DDC1 gene belongs to the RAD17, MEC3 and RAD24 …
The functions of budding yeast Sae2 in the DNA damage response require Mec1-and Tel1-dependent phosphorylation
E Baroni, V Viscardi, H Cartagena-Lirola… - … and cellular biology, 2004 - Am Soc Microbiol
DNA damage checkpoint pathways sense DNA lesions and transduce the signals into
appropriate biological responses, including cell cycle arrest, induction of transcriptional …
appropriate biological responses, including cell cycle arrest, induction of transcriptional …
[HTML][HTML] The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1‐dependent hyperphosphorylation and interacts with Rad53 after DNA damage
JE Vialard, CS Gilbert, CM Green, NF Lowndes - The EMBO journal, 1998 - embopress.org
The Saccharomyces cerevisiae RAD9 checkpoint gene is required for transient cell‐cycle
arrests and transcriptional induction of DNA repair genes in response to DNA damage …
arrests and transcriptional induction of DNA repair genes in response to DNA damage …
[PDF][PDF] Mec1ATR autophosphorylation and Ddc2ATRIP phosphorylation regulates DNA damage checkpoint signaling
In budding yeast, a single DNA double-strand break (DSB) triggers the activation of Mec1
ATR-dependent DNA damage checkpoint. After about 12 h, cells turn off the checkpoint …
ATR-dependent DNA damage checkpoint. After about 12 h, cells turn off the checkpoint …
Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway
T Kondo, K Matsumoto, K Sugimoto - Molecular and cellular …, 1999 - Taylor & Francis
Genetic analysis has suggested that RAD17, RAD24, MEC3, and DDC1 play similar roles in
the DNA damage checkpoint control in budding yeast. These genes are required for DNA …
the DNA damage checkpoint control in budding yeast. These genes are required for DNA …