In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of
many cytosine residues to 5-methylcytosine. For several years, control of gene activity by …

The distribution of 5-methylcytosine (m5C) in vertebrate genomes is strikingly different from
that in all other animal genomes that have been examined. In the vertebrates, almost all …

Recent advances have expanded our understanding of the processes underlying the
establishment, maintenance, and elaboration of DNA methylation patterns in eukaryotes …

An obstacle to progress in understanding eukaryotic DNA methylation has been the lack of a
good genetic systemthe most favorable eukaryotes for genetic analysis (yeasts …

It has been nearly 40 y since it was suggested that genomic methylation patterns could be
transmitted via maintenance methylation during S phase and might play a role in the …

The regulation of gene transcription is not simply dependent on the presence or absence of
DNA-binding transcription factors that turn genes on or off, but also involves processes …

ARE changes in DNA methylation patterns a cause or an effect of eukaryotic gene
expression? There are already many examples of an inverse correlation between the level …

The amino acid sequence of mammalian DNA methyltransferase has been deduced from
the nucleotide sequence of a cloned cDNA. It appears that the mammalian enzyme arose …

Cytosine methylation is a com-mon DNA modification found in most eukaryotic organisms
including plants, animals, and fungi (1, 2). The addition of a methyl group to cytosine …

DNA methylation on cytosine is an epigenetic modification and is essential for gene
regulation and genome stability in vertebrates. Traditionally DNA methylation was …