Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers
JE Ippolito, ME Merritt, F Bäckhed… - Proceedings of the …, 2006 - National Acad Sciences
To identify metabolic features that support the aggressive behavior of human
neuroendocrine (NE) cancers, we examined metastatic prostate NE tumors and derived …
neuroendocrine (NE) cancers, we examined metastatic prostate NE tumors and derived …
An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers
Human neuroendocrine (NE) cancers range from relatively indolent to highly aggressive. In
this study, we combine functional genomics with metabolomics to identify features of NE …
this study, we combine functional genomics with metabolomics to identify features of NE …
[HTML][HTML] A landscape of metabolic variation across tumor types
Tumor metabolism is reorganized to support proliferation in the face of growth-related stress.
Unlike the widespread profiling of changes to metabolic enzyme levels in cancer …
Unlike the widespread profiling of changes to metabolic enzyme levels in cancer …
[HTML][HTML] Exploring the role of metabolites in cancer and the associated nerve crosstalk
Since Otto Warburg's first report on the increased uptake of glucose and lactate release by
cancer cells, dysregulated metabolism has been acknowledged as a hallmark of cancer that …
cancer cells, dysregulated metabolism has been acknowledged as a hallmark of cancer that …
[HTML][HTML] Imaging mass spectrometry reveals tumor metabolic heterogeneity
Malignant tumors exhibit high degrees of genomic heterogeneity at the cellular level,
leading to the view that subpopulations of tumor cells drive growth and treatment resistance …
leading to the view that subpopulations of tumor cells drive growth and treatment resistance …
[HTML][HTML] The hallmarks of cancer metabolism: Still emerging
Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors
I Marin‐Valencia, SK Cho, D Rakheja… - NMR in …, 2012 - Wiley Online Library
It has been hypothesized that increased flux through the pentose phosphate pathway (PPP)
is required to support the metabolic demands of rapid malignant cell growth. Using …
is required to support the metabolic demands of rapid malignant cell growth. Using …
Multi-substrate metabolic tracing reveals marked heterogeneity and dependency on fatty acid metabolism in human prostate cancer
Cancer cells undergo metabolic reprogramming to meet increased bioenergetic demands.
Studies in cells and mice have highlighted the importance of oxidative metabolism and …
Studies in cells and mice have highlighted the importance of oxidative metabolism and …
[HTML][HTML] Metabolic differences in glutamine utilization lead to metabolic vulnerabilities in prostate cancer
NM Zacharias, C McCullough, S Shanmugavelandy… - Scientific reports, 2017 - nature.com
The new oncologic paradigm of precision medicine is focused on identifying metabolic,
proteomic, transcriptomic and genomic variabilities in tumors that can be exploited to tailor …
proteomic, transcriptomic and genomic variabilities in tumors that can be exploited to tailor …
[HTML][HTML] Metabolic alterations in pancreatic cancer progression
Pancreatic cancer is the third leading cause of cancer-related deaths in the USA. Pancreatic
tumors are characterized by enhanced glycolytic metabolism promoted by a hypoxic tumor …
tumors are characterized by enhanced glycolytic metabolism promoted by a hypoxic tumor …