METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis
METTL16 has recently been identified as an RNA methyltransferase responsible for the
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …
[HTML][HTML] The m6A methyltransferase METTL3 promotes translation in human cancer cells
METTL3 is an RNA methyltransferase implicated in mRNA biogenesis, decay, and
translation control through N 6-methyladenosine (m 6 A) modification. Here we find that …
translation control through N 6-methyladenosine (m 6 A) modification. Here we find that …
Methylation of structured RNA by the m6A writer METTL16 is essential for mouse embryonic development
Internal modification of RNAs with N 6-methyladenosine (m 6 A) is a highly conserved
means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark …
means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark …
METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis
X Wei, Y Huo, J Pi, Y Gao, S Rao, M He, Q Wei… - Nature cell …, 2022 - nature.com
METTL3 encodes the predominant catalytic enzyme to promote m6A methylation in nucleus.
Recently, accumulating evidence has shown the expression of METTL3 in cytoplasm, but its …
Recently, accumulating evidence has shown the expression of METTL3 in cytoplasm, but its …
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
Abstract N 6-methyladenosine (m6A) is an abundant internal RNA modification in both
coding and non-coding RNAs, that is catalysed by the METTL3–METTL14 methyltransferase …
coding and non-coding RNAs, that is catalysed by the METTL3–METTL14 methyltransferase …
The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation
Ribosomal RNAs (rRNAs) have long been known to carry chemical modifications, including
2′ O-methylation, pseudouridylation, N 6-methyladenosine (m 6 A), and N 6, 6 …
2′ O-methylation, pseudouridylation, N 6-methyladenosine (m 6 A), and N 6, 6 …
Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
X Liu, H Wang, X Zhao, Q Luo, Q Wang, K Tan… - Nature …, 2021 - nature.com
Abstract RNA N 6-methyladenosine (m6A), the most abundant internal modification of
mRNAs, plays key roles in human development and health. Post-translational methylation of …
mRNAs, plays key roles in human development and health. Post-translational methylation of …
m6A deposition is regulated by PRMT1‐mediated arginine methylation of METTL14 in its disordered C‐terminal region
Abstract The N6‐methyladenosine (m6A) RNA modification serves crucial functions in RNA
metabolism; however, the molecular mechanisms underlying the regulation of m6A are not …
metabolism; however, the molecular mechanisms underlying the regulation of m6A are not …
A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Abstract N 6-methyladenosine (m6A) is the most prevalent and reversible internal
modification in mammalian messenger and noncoding RNAs. We report here that human …
modification in mammalian messenger and noncoding RNAs. We report here that human …
Human METTL16 is a N6‐methyladenosine (m6A) methyltransferase that targets pre‐mRNAs and various non‐coding RNAs
AS Warda, J Kretschmer, P Hackert, C Lenz… - EMBO …, 2017 - embopress.org
Abstract N 6‐methyladenosine (m6A) is a highly dynamic RNA modification that has recently
emerged as a key regulator of gene expression. While many m6A modifications are installed …
emerged as a key regulator of gene expression. While many m6A modifications are installed …