[HTML][HTML] Pan-cancer analysis of whole genomes
Nature, 2020 - nature.com
Cancer is driven by genetic change, and the advent of massively parallel sequencing has
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …
Pan-cancer analysis of whole genomes
T Underwood - Nature, 2020 - eprints.soton.ac.uk
Cancer is driven by genetic change, and the advent of massively parallel sequencing has
enabled systematic documentation of this variation at the whole-genome scale1-3. Here we …
enabled systematic documentation of this variation at the whole-genome scale1-3. Here we …
[HTML][HTML] The evolutionary history of 2,658 cancers
Cancer develops through a process of somatic evolution,. Sequencing data from a single
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …
Systematic analysis of telomere length and somatic alterations in 31 cancer types
Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across …
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across …
Cancer chromosomes in crisis
RA DePinho, K Polyak - Nature genetics, 2004 - nature.com
The benign-to-malignant transition in human breast cancer is associated with a marked
increase in chromosomal aberrations. A new study suggests that telomere dysfunction and …
increase in chromosomal aberrations. A new study suggests that telomere dysfunction and …
[HTML][HTML] International network of cancer genome projects
International Cancer Genome Consortium - Nature, 2010 - ncbi.nlm.nih.gov
Abstract The International Cancer Genome Consortium (ICGC) was launched to coordinate
large-scale cancer genome studies in tumors from 50 different cancer types and/or subtypes …
large-scale cancer genome studies in tumors from 50 different cancer types and/or subtypes …
[HTML][HTML] The repertoire of mutational signatures in human cancer
Somatic mutations in cancer genomes are caused by multiple mutational processes, each of
which generates a characteristic mutational signature. Here, as part of the Pan-Cancer …
which generates a characteristic mutational signature. Here, as part of the Pan-Cancer …
[HTML][HTML] Pan-cancer whole-genome comparison of primary and metastatic solid tumours
F Martínez-Jiménez, A Movasati, SR Brunner… - Nature, 2023 - nature.com
Metastatic cancer remains an almost inevitably lethal disease,–. A better understanding of
disease progression and response to therapies therefore remains of utmost importance …
disease progression and response to therapies therefore remains of utmost importance …
[HTML][HTML] Mutational landscape and significance across 12 major cancer types
Abstract The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis
methods to identify somatic variants across thousands of tumours. Here we present data and …
methods to identify somatic variants across thousands of tumours. Here we present data and …
Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
Telomeres consist of short repeated sequences that are synthesized by telomerase, a
ribonucleo-protein DMA polymerase1–4. Telomerase activity is present in many tumours …
ribonucleo-protein DMA polymerase1–4. Telomerase activity is present in many tumours …