Background Inherited mutations in DNA-repair genes such as BRCA2 are associated with
increased risks of lethal prostate cancer. Although the prevalence of germline mutations in …

Background DNA repair gene mutations are present in 8–10% of localized prostate cancers.
It is unknown whether this is influenced by clinicopathologic factors. Methods We …

Background There is an urgent need to identify factors specifically associated with
aggressive prostate cancer (PCa) risk. We investigated whether rare pathogenic, likely …

Background Germline mutations in genes mediating DNA repair are common in men with
recurrent and advanced prostate cancer, and their presence may alter prognosis and …

Germline and somatic aberrations in DNA damage repair (DDR) genes are more prevalent
in prostate cancer than previously recognized, with BRCA2 as the most commonly altered …

Background Rare germline mutations in DNA repair genes are associated with prostate
cancer (PCa) predisposition and prognosis. Objective To quantify the frequency of germline …

Over the past years, several studies have demonstrated that defects in DNA damage
response and repair (DDR) genes are present in a significant proportion of patients with …

Purpose: Increased prostate cancer risk has been reported for BRCA mutation carriers, but
BRCA-associated clinicopathologic features have not been clearly defined. Experimental …

Genetic testing for prostate cancer (PCa) patients is in constant development. Specific
genetic alterations indicate personalized managing strategies, requiring clinicians to refer …

Purpose Germline mutations in DNA damage repair (DDR) genes are identified in a
significant proportion of patients with metastatic prostate cancer, but the clinical implications …