Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell
phenotypes shaped by the TCR. - Abstract - Europe PMC Sign in | Create an account https://orcid.org …

CD4+ T regulatory cells (Treg) are central to immune homeostasis, their phenotypic
heterogeneity reflecting the diverse environments and target cells that they regulate. To …

The T cell antigen receptor (TCR) is unique in that its affinity for ligand is unknown before
encounter and can vary by orders of magnitude. How the immune system regulates …

T cell antigen receptor (TCR)-transgenic models have been enormously influential in studies
of T cell development in the thymus, particularly in terms of positive and negative selection …

The physiological basis and mechanistic requirements for a large number of functional
immunoreceptor tyrosine-based activation motifs (ITAMs; high ITAM multiplicity) in the …

Parsing the transcription factors governing T cell immunity | Nature Immunology Skip to
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I have spent more than the last 40 years at the University of California, San Francisco
(UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an …

Abstract Despite accounting for 10–30% of the T cell population in mice and humans, the
role of dual TCR-expressing T cells in immunity remains poorly understood. It has been …

T cells use the αβ TCR to bind peptides presented by MHC proteins (pMHC) on APCs.
Formation of a TCR–pMHC complex initiates T cell signaling via a poorly understood …

Dynamic changes in the expression of transcription factors (TFs) can influence the
specification of distinct CD8+ T cell fates, but the observation of equivalent expression of TFs …