An amphiphilic nanoassembly was designed to respond to the concurrent presence of a
protein and an enzyme. We present herein a system, where in the presence of these two …

Mimicking noncovalent interaction based processes in nature has been an important goal of
supramolecular chemistry. Here, we report on amphiphilic polypeptides that self-assemble …

Disassembling a supramolecular assembly and releasing the contents of the assembly in
response to a stimulus are important goals of supramolecular chemistry. When proteins are …

We demonstrate a new enzyme-induced disassembly of amphiphilic nanocontainers based
on dendrimers. Disassembly and the ensuing release of noncovalently bound guest …

We use monodisperse dendrons that allow control over functional group presentation to
investigate the influence of the location of a ligand on protein-induced disassembly and …

Proteins, as the elemental basis of living organisms, mostly execute their biological tasks in
the form of supramolecular self-assemblies with subtle architectures, dynamic interactions …

“Switchable” fluorescent probes, which induce changes in the fluorescence properties (eg,
intensity and/or wavelength) only at the intended target protein, are particularly useful for …

The concurrence of enzymatic reaction and ligand–receptor interactions is common for
proteins, but rare for small molecules and has yet to be explored. Here we show that ligand …

The regulation of recognition events in nature via dynamic and reversible self-assembly of
building blocks has inspired the emergence of supramolecular architectures with similar …

We report a new molecular design strategy that allows for the propagation of surface
enzymatic events inside a supramolecular assembly for accelerated molecular release. The …