[HTML][HTML] Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses

F Hellgren, A Cagigi, R Arcoverde Cerveira… - Nature …, 2023 - nature.com
Licensed rabies virus vaccines based on whole inactivated virus are effective in humans.
However, there is a lack of detailed investigations of the elicited immune response, and …

[HTML][HTML] A single vaccination of nucleoside-modified Rabies mRNA vaccine induces prolonged highly protective immune responses in mice

S Bai, T Yang, C Zhu, M Feng, L Zhang… - Frontiers in …, 2023 - frontiersin.org
Background Rabies is a lethal zoonotic disease that kills approximately 60,000 people each
year. Although inactivated rabies vaccines are available, multiple-dose regimensare …

[HTML][HTML] An mRNA-based rabies vaccine induces strong protective immune responses in mice and dogs

J Li, Q Liu, J Liu, X Wu, Y Lei, S Li, D Zhao, Z Li, L Luo… - Virology Journal, 2022 - Springer
Rabies is a lethal zoonotic disease that is mainly caused by the rabies virus (RABV).
Although effective vaccines have long existed, current vaccines take both time and cost to …

[HTML][HTML] An mRNA vaccine encoding rabies virus glycoprotein induces protection against lethal infection in mice and correlates of protection in adult and newborn pigs

M Schnee, AB Vogel, D Voss, B Petsch… - PLoS neglected …, 2016 - journals.plos.org
Rabies is a zoonotic infectious disease of the central nervous system (CNS). In
unvaccinated or untreated subjects, rabies virus infection causes severe neurological …

[HTML][HTML] An mRNA vaccine against rabies provides strong and durable protection in mice

M Li, E Fang, Y Wang, L Shi, J Li, Q Peng, X Li… - Frontiers in …, 2023 - frontiersin.org
Introduction Rabies is a serious public health problem worldwide for which an effective
treatment method is lacking but can be prevented by vaccines. Current vaccines are …

Proof-of-concept of a low-dose unmodified mRNA-based rabies vaccine formulated with lipid nanoparticles in human volunteers: A phase 1 trial

C Aldrich, I Leroux–Roels, KB Huang, MA Bica… - Vaccine, 2021 - Elsevier
Introduction In a first-in-human study immune responses to rabies virus glycoprotein (RABV-
G)-mRNA vaccine were dependent on the route of administration, necessitating specialized …

[HTML][HTML] Advances in RNA vaccines for preventive indications: a case study of a vaccine against rabies

N Armbruster, E Jasny, B Petsch - Vaccines, 2019 - mdpi.com
There is a global need for effective and affordable rabies vaccines, which is unmet by
current vaccines due to limitations in their production capacities, required administration …

A single immunization with core–shell structured lipopolyplex mRNA vaccine against rabies induces potent humoral immunity in mice and dogs

J Wan, J Yang, Z Wang, R Shen, C Zhang… - Emerging Microbes & …, 2023 - Taylor & Francis
The persistence and clinical consequences of rabies virus (RABV) infection have prompted
global efforts to develop a safe and effective vaccines against rabies. mRNA vaccines …

Overexpression of interleukin-7 extends the humoral immune response induced by rabies vaccination

Y Li, M Zhou, Z Luo, Y Zhang, M Cui, H Chen… - Journal of …, 2017 - Am Soc Microbiol
Rabies continues to present a public health threat in most countries of the world. The most
efficient way to prevent and control rabies is to implement vaccination programs for domestic …

[HTML][HTML] Recombinant rabies viruses expressing GM-CSF or flagellin are effective vaccines for both intramuscular and oral immunizations

M Zhou, G Zhang, G Ren, CW Gnanadurai, Z Li… - PloS one, 2013 - journals.plos.org
Our previous studies indicated that recombinant rabies viruses (rRABV) expressing
chemokines or cytokines (including GM-CSF) could enhance the immunogenicity by …