Brain metastases (BM) are the most common brain tumor in adults and are a leading cause
of cancer mortality. Metastatic lesions contain subclones derived from their primary lesion …

Dissemination of cancer cells from primary tumors to the brain occurs in many cancer
patients, increasing morbidity and death. There is an unmet medical need to develop …

Brain metastases (BM) result from the spread of primary tumors to the brain and are a
leading cause of cancer mortality in adults. Secondary tissue colonization remains the main …

Background Brain metastases are most common in adults with lung cancer, predicting
uniformly poor patient outcome, with a median survival of only months. Despite their …

Background & Aims Brain metastases (BMs) from colorectal cancer (CRC) are associated
with significant morbidity and mortality, with chemoresistance and short overall survival …

Lung cancer is the leading cause of cancer related death worldwide and the prognosis is
still poor with 5-year survival of approximately 15%. Metastasis is the leading cause of death …

Brain metastasis (BrM) is the most common form of brain cancer, characterized by
neurologic disability and an abysmal prognosis. Unfortunately, our understanding of the …

Brain metastases (BMs) are the most common brain tumor in adults, developing in about
10% of adult cancer patients. It is not the incidence of BM that is alarming, but the poor …

Brain metastases (BM) are the most common brain neoplasm in adults. Current BM
therapies still offer limited efficacy and reduced survival outcomes, emphasizing the need for …

Cancer metastasis is the major cause of cancer‐related death despite significant
improvements in multimodal cancer therapy. Epithelial–mesenchymal transition (EMT), a …