Genetic studies based on single-nucleotide polymorphisms have provided valuable insights
into the genetic architecture of complex diseases. However, a large fraction of heritability for …

To explore the contribution of functional coding variants to psoriasis, we analyzed
nonsynonymous single-nucleotide variants (SNVs) across the genome by exome …

In a previous large-scale exome sequencing analysis for psoriasis, we discovered seven
common and low-frequency missense variants within six genes with genome-wide …

Most psoriasis-related genes or loci identified by GWAS represent common clusters and are
located in noncoding regions of the human genome, providing only limited evidence for the …

Genome-wide association studies (GWASs) have reproducibly associated∼ 40
susceptibility loci with psoriasis. However, the missing heritability is evident and the …

Although genome-wide association studies have revealed important insights into the global
genetic basis of psoriasis, the findings require further investigation. At present, the known …

Background Genome-wide association studies have identified over 120 risk loci for
psoriasis. However, most of the variations are located in non-coding region with high …

Psoriasis is a chronic and multifactorial skin disease affecting B2% of the population
worldwide (Griffiths and Barker, 2007). There is a higher risk of psoriasis among …

Psoriasis is a common inflammatory skin disease, with considerable genetic contribution.
Genome-wide association studies have successfully identified a number of genomic regions …

Although> 80 psoriasis genetic risk loci have been reported through genome-wide
association studies (GWASs), the genetic mechanism of psoriasis remains unclear. To …