Early prediction of clinical outcomes in resected stage II and III colorectal cancer (CRC) through deep sequencing of circulating tumor DNA (ctDNA).

M Diehn, AA Alizadeh, HP Adams, JJ Lee, S Klassen… - 2017 - ascopubs.org
3591 Background: Adjuvant chemotherapy is offered to most pts with Stage III CRC, and to a
subset with Stage II disease deemed at high-risk for recurrence. Nevertheless, risk …

Circulating tumor DNA in stage III colorectal cancer, beyond minimal residual disease detection, toward assessment of adjuvant therapy efficacy and clinical behavior …

TV Henriksen, N Tarazona, A Frydendahl… - Clinical Cancer …, 2022 - AACR
Purpose: Sensitive methods for risk stratification, monitoring therapeutic efficacy, and early
relapse detection may have a major impact on treatment decisions and patient management …

Circulating tumor DNA (ctDNA) for informing adjuvant chemotherapy (ACT) in stage II/III colorectal cancer (CRC): Interim analysis of BESPOKE CRC study.

PM Kasi, VN Aushev, J Ensor, N Langer, CG Wang… - 2024 - ascopubs.org
9 Background: ctDNA-based post-surgical detection of molecular residual disease (MRD) is
known to be predictive of a high risk of recurrence. Here, we report the first results of …

Circulating tumor DNA to detect minimal residual disease, response to adjuvant therapy, and identify patients at high risk of recurrence in patients with stage I-III CRC.

N Tarazona, TV Henriksen, JA Carbonell-Asins… - 2020 - ascopubs.org
4009 Background: The clinical utility of tracking circulating tumor DNA (ctDNA) as a non-
invasive biomarker for detecting minimal residual disease (MRD) and stratifying patients …

Circulating tumor DNA analysis predicts recurrence and avoids unnecessary adjuvant chemotherapy in I–IV colorectal cancer

W Fan, Z Xia, R Chen, D Lin, F Li… - Therapeutic …, 2024 - journals.sagepub.com
Background: Circulating tumor DNA (ctDNA) has emerged as a biomarker that can define
the risk of recurrence after curative-intent surgery for patients with colorectal cancer (CRC) …

[HTML][HTML] Serial circulating tumor DNA analysis for detection of residual disease, assessment of adjuvant therapy efficacy and for early recurrence detection in colorectal …

T Reinert, TV Henriksen, MH Rasmussen… - Annals of …, 2018 - annalsofoncology.org
Background: Early detection of disease recurrence has been shown to improve survival in
patients with colorectal cancer (CRC). Previous studies have analyzed circulating tumor …

Phase II results of circulating tumor DNA as a predictive biomarker in adjuvant chemotherapy in patients with stage II colon cancer: NRG-GI005 (COBRA) phase II/III …

VK Morris, G Yothers, S Kopetz, SL Puhalla, PC Lucas… - 2024 - ascopubs.org
5 Background: For patients (pts) with colon cancer (CC), the detection of circulating tumor
DNA (ctDNA) is associated with persistent disease after resection and outperforms …

Postoperative circulating tumor DNA can predict high risk patients with colorectal cancer based on next-generation sequencing

CS Lee, HS Kim, J Schageman, IK Lee, M Kim, Y Kim - Cancers, 2021 - mdpi.com
Simple Summary Circulating tumor DNA (ctDNA) is a minimally invasive biomarker useful for
monitoring minimum residual disease, recurrence, and treatment response in colorectal …

A plasma-only integrated genomic and epigenomic circulating tumor DNA (ctDNA) assay to inform recurrence risk in colorectal cancer (CRC).

AR Parikh, EE Van Seventer, GM Boland, A Hartwig… - 2019 - ascopubs.org
3602 Background: ctDNA identifies patients (pts) at high risk for disease recurrence post
CRC resection (post-op). Current ctDNA residual disease detection approaches assess only …

Tumor-informed or tumor-agnostic circulating tumor DNA as a biomarker for risk of recurrence in resected colorectal cancer patients

HT Chan, S Nagayama, M Otaki, YM Chin… - Frontiers in …, 2023 - frontiersin.org
Introduction Circulating tumor DNA (ctDNA) has been increasingly recognized as a
promising minimally-invasive biomarker that could identify patients with minimal residual …