The end of human telomeres is comprised of a long G-rich single-stranded DNA (known as
3′-overhang) able to adopt an unusual three-dimensional “beads-on-the-string” …

The telomeric G-rich single-stranded DNA can adopt in vitro an intramolecular quadruplex
structure, which has been shown to directly inhibit telomerase activity. The reactivation of …

Telomeric DNA can assemble into a nonlinear, higher-order conformation known as a G-
quadruplex. Here, we demonstrate by electrospray ionization mass spectrometry that the two …

RNA and DNA guanine-rich sequences can adopt unusual structures called Guanine
quadruplexes (G4). A quadruplex-prone RNA sequence is present at the 5′-end of the 451 …

The 3′ human telomeric overhang provides ample opportunities for the formation and
interaction of G-quadruplexes, which have shown impacts on many biological functions …

Telomerase is responsible for the immortal phenotype of cancer cells and telomerase
inhibition may specifically target cancer cell proliferation. Ligands able to selectively bind to …

Telomerase is a promising “universal” anticancer target. It has been demonstrated that
inhibition of telomerase leads to mortalization and death of previously immortal cell lines …

The G-rich strand of human telomeric DNA can fold into a four-stranded structure called G-
quadruplex and inhibit telomerase activity that is expressed in 85− 90% tumor cells. For this …

The telomeres cap and protect the eukaryotic chromosome ends from undesired
degradation and end-to-end fusion. They consist of short tandem DNA repeats (TTAGGG in …

Quadruplex ligands are often considered as telomerase inhibitors. Given the fact that some
of these molecules are present in the clinical setting, it is important to establish the validity of …