Cancer is characterized by hypomethylation-associated silencing of large chromatin
domains, whose contribution to tumorigenesis is uncertain. Through high-resolution genome …

DNA methylation plays a critical role in establishing and maintaining cellular identity.
However, it is frequently dysregulated during tumor development and is closely intertwined …

Hypomethylation of CpG dinucleotides in genomic DNA was one of the first somatic
epigenetic alterations discovered in human cancers. DNA hypomethylation is postulated to …

DNA methylation, occurring at cytosines in CpG dinucleotides, is a potent mechanism of
transcriptional repression. Proper genomic methylation patterns become profoundly altered …

Altered signaling pathways resulting from aberrant changes in epigenetic parameters may
play a pivotal role in carcinogenesis. To identify biological pathways likely to be affected by …

Altered genome methylation is a hallmark of human malignancies. In this study, high-
throughput analyses of concordant gene methylation and expression events were performed …

Transcriptional silencing associated with aberrant promoter hypermethylation is a common
mechanism of inactivation of tumor suppressor genes in cancer cells. To globally profile the …

This study was designed to determine if cytological detection of 5-methylcytosine (5MC) was
feasible on prostate tumor sections and to determine if levels of 5MC differed in malignant …

Abstract Background Prostate cancer (PCa) has the highest incidence rates of cancers in
men in western countries. Unlike several other types of cancer, PCa has few genetic drivers …

Abstract Background The Cancer/Testis Antigens (CTAs) are a heterogeneous group of
proteins whose expression is typically restricted to the testis. However, they are aberrantly …