Surgical correction of unilateral coronal synostosis offers a unique opportunity to examine
the molecular differences between an abnormal and a normal cranial suture. We isolated …

Previously, we reported NELL-1 as a novel molecule overexpressed during premature
cranial suture closure in patients with craniosynostosis (CS), one of the most common …

We studied the cellular function of Nell‐1, a craniosynostosis‐related gene, in craniofacial
development. Nell‐1 modulates calvarial osteoblast differentiation and apoptosis pathways …

The mammalian Nell1 gene encodes a protein kinase C-β1 (PKC-β1) binding protein that
belongs to a new class of cell-signaling molecules controlling cell growth and differentiation …

Many craniofacial birth defects contain skeletal components requiring bone grafting. We
previously identified the novel secreted osteogenic molecule NELL-1, first noted to be …

We studied the transcriptional regulation of NELL‐1, a craniosynostosis‐related gene. We
identitifed three OSE2 elements in the NELL‐1 promoter that are directly bound and …

Background: Effective regeneration of bone is critical for fracture repair and incorporation
and healing of bone grafts used during orthopedic, dental, and craniofacial reconstructions …

Nel-like protein 1 (NELL-1) is an osteoinductive molecule associated with premature
calvarial suture closure. Here we identified apoptosis related protein 3 (APR3), a membrane …

NELL-1 is a secreted, osteoinductive protein whose expression rheostatically controls
skeletal ossification. Overexpression of NELL-1 results in craniosynostosis in humans and …

BACKGROUND CONTEXT: Recombinant growth factors bone morphogenetic protein-2
(BMP-2) and BMP-7 are currently approved for human use but are associated with various …