Endothelial colony-forming cells (ECFCs) are obtained from the culture of human peripheral
blood mononuclear cell (hPBMNC) fractions and are characterised by high proliferative and …

Abstract Objective: Protease-activated receptors (PARs) mediate DNA synthesis in
endothelial cells when activated by serine proteases. However, despite the existence of …

Several studies have shown significant heterogeneity among endothelial progenitor cell
(EPC) populations. At least two types of EPC have been described [1]. ÔEarlyÕ EPCs …

Background The involvement of thrombin receptor PAR1 in blood vessel development has
been largely demonstrated in knockout mice; however, its implication in adult mouse …

Objectives: The importance of protease‐activated receptor‐1 (PAR‐1) in blood vessel
development has been shown in knock‐out mice. As endothelial progenitor cells (EPCs) …

Protease activated receptors (PARs) are a small family of G protein-coupled receptors
(GPCR) mediating the cellular effects of some proteases of the coagulation system, such as …

The present study investigates whether vascular smooth muscle cells of the human
saphenous vein (SMC) express a functionally active protease-activated receptor-3 (PAR-3) …

Endothelial cells express several types of integral membrane protein receptors, which upon
interaction and activation by their specific ligands, initiate a signalling network that links …

The serine protease thrombin, independently of its participation in hemostasis and
thrombosis, has been involved in tissue repair and remodeling, embryogenesis …

Objective—Emerging evidence suggests that protease-activated receptors-1 and-2 (PAR1
and PAR2) can signal together in response to proteases found in the rapidly changing …