Gastrodin Protects Apoptotic Dopaminergic Neurons in a Toxin‐Induced Parkinson's Disease Model

H Kumar, IS Kim, SV More, BW Kim… - Evidence‐Based …, 2013 - Wiley Online Library
Gastrodia elata (GE) Blume is one of the most important traditional plants in Oriental
countries and has been used for centuries to improve various conditions. The phenolic …

Protective effects of Gastrodia elata Blume on MPP+-induced cytotoxicity in human dopaminergic SH-SY5Y cells

H An, IS Kim, S Koppula, BW Kim, PJ Park… - Journal of …, 2010 - Elsevier
AIM OF THE STUDY: Gastrodia elata (GE) Blume (Orchidaceae) has been traditionally used
as a folk medicine in Oriental countries since centuries for their variety of therapeutic …

[HTML][HTML] Neuroprotective Effects of Vanillyl Alcohol in Gastrodia elata Blume Through Suppression of Oxidative Stress and Anti-Apoptotic Activity in Toxin-Induced …

IS Kim, DK Choi, HJ Jung - Molecules, 2011 - mdpi.com
Gastrodia elata Blume (GE) has long been used in oriental countries as a traditional herbal
medicine to relieve symptoms associated with neurological ailments such as vertigo …

Gastrodin protects against MPP+-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK/Nrf2 pathway in human dopaminergic …

G Jiang, Y Hu, L Liu, J Cai, C Peng, Q Li - Neurochemistry international, 2014 - Elsevier
Although the etiology of PD remains unclear, increasing evidence has shown that oxidative
stress plays an important role in its pathogenesis and that of other neurodegenerative …

Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson's disease: Involvement of ERK1/2–Nrf2 signaling pathway

XL Wang, GH Xing, B Hong, XM Li, Y Zou, XJ Zhang… - Life sciences, 2014 - Elsevier
Aims Current no effective therapy is available to halt the progression of Parkinson's disease
(PD). Oxidative stress has been implicated in the etiology of PD. The present study …

A Preclinical Systematic Review of Ginsenoside‐Rg1 in Experimental Parkinson's Disease

L Song, MB Xu, XL Zhou, D Zhang… - Oxidative Medicine …, 2017 - Wiley Online Library
To date, no drug has been proven to be neuroprotective or disease‐modifying for
Parkinson's disease (PD) in clinical trials. Here, we aimed to assess preclinical evidence of …

Neuroprotective benefits of grape seed and skin extract in a mouse model of Parkinson's disease

S Ben Youssef, G Brisson… - Nutritional …, 2021 - Taylor & Francis
Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss
of midbrain dopaminergic (mDA) neurons in the substantia nigra pars compacta, and it …

Gastrodia elata polysaccharide alleviates Parkinson's disease via inhibiting apoptotic and inflammatory signaling pathways and modulating the gut microbiota

Q Gan, M Peng, H Wei, L Chen, X Chen, Z Li, G An… - Food & function, 2024 - pubs.rsc.org
Parkinson's disease (PD) is a common, chronic, and progressive degenerative disease of
the central nervous system for which there is no effective treatment. Gastrodia elata is a well …

Gastrodia elata Shows Neuroprotective Effects via Activation of PI3K Signaling against Oxidative Glutamate Toxicity in HT22 Cells

YJ Han, JH Je, SH Kim, SM Ahn, HN Kim… - The American journal …, 2014 - World Scientific
Dried roots of Gastrodia elata have traditionally been used in Korean medicine for the
treatment of neurological disorders such as scotodinia, paralysis, and epilepsy. In our study …

[HTML][HTML] Effects of gastrodin against lead-induced brain injury in mice associated with the Wnt/Nrf2 pathway

CM Liu, ZK Tian, YJ Zhang, QL Ming, JQ Ma, LP Ji - Nutrients, 2020 - mdpi.com
Gastrodin (GAS), the main phenolic glycoside extracted from Gastrodia elata Blume,
exhibited potential neuroprotective properties. Here we examined the protective effects of …