Complement activation has a role in the pathogenesis of IgA nephropathy, an autoimmune
disease mediated by pathogenic immune complexes consisting of galactose-deficient IgA1 …

IgA nephropathy (IgAN) is common and often progresses to end stage renal disease. IgAN
encompasses a wide range of histology and clinical features. IgAN pathogenesis is …

Primary IgA nephropathy (IgAN) is a leading cause of chronic kidney disease and kidney
failure for which there is no disease-specific treatment. However, this could change, since …

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide
and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is …

Here we discuss recent advances in understanding the biochemical, immunologic, and
genetic pathogenesis of IgA nephropathy, the most common primary glomerulonephritis …

Immunoglobulin A nephropathy (IgAN) is characterized by the deposition of IgA in the
mesangium of glomeruli. This mesangial IgA has been found to consist mainly of polymeric …

IgA nephropathy (IgAN) is the most common primary glomerulonephritis, frequently leading
to end-stage renal disease, as there is no disease-specific therapy. IgAN is diagnosed from …

IgA nephropathy (IgAN) is characterized by glomerular co-deposition of IgA and complement
components. Earlier studies showed that IgA activates the alternative pathway of …

Results There were 109 patients (38.5%) and 174 patients (61.5%) who were classified as
C4d positive and C4d negative, respectively. Renal survival at 20 years was 28% in C4d …

Three pathways are recognized in complement activation. The aim of our study is to
elucidate immunohistologically which complement pathway is associated with complement …