Synthesis and antiproliferative activity of novel dehydroabietic acid-chalcone hybrids

S Grigoropoulou, D Manou, AI Antoniou, A Tsirogianni… - Molecules, 2022 - mdpi.com
Dehydroabietic Acid (DHA, 1) derivatives are known for their antiproliferative properties,
among others. In the context of this work, DHA was initially modified to two key intermediates …

Synthesis and antiproliferative activity of some novel triazole derivatives from dehydroabietic acid

MW Pertino, V Verdugo, C Theoduloz… - Molecules, 2014 - mdpi.com
Dehydroabietic acid (DHA) is a naturally occurring diterpene with different and relevant
biological activities. Previous studies have shown that some DHA derivatives display …

Synthesis and antiproliferative evaluation of novel hybrids of dehydroabietic acid bearing 1, 2, 3-triazole moiety

FY Li, L Huang, Q Li, X Wang, XL Ma, CN Jiang… - Molecules, 2019 - mdpi.com
To discover novel potent cytotoxic diterpenoids, a series of hybrids of dehydroabietic acid
containing 1, 2, 3-triazole moiety were designed and synthesized. The target compounds …

Synthesis and evaluation of new quinoxaline derivatives of dehydroabietic acid as potential antitumor agents

W Gu, S Wang, X Jin, Y Zhang, D Hua, T Miao, X Tao… - Molecules, 2017 - mdpi.com
A series of new quinoxaline derivatives of dehydroabietic acid (DAA) were designed and
synthesized as potential antitumor agents. Their structures were characterized by IR, 1H …

Synthesis and biological evaluation of dehydroabietic acid-pyrimidine hybrids as antitumor agents

L Huang, R Huang, F Pang, A Li, G Huang, X Zhou… - RSC …, 2020 - pubs.rsc.org
A series of novel dehydroabietic acid derivatives containing pyrimidine moieties were
designed and synthesized to explore more efficacious and less toxic antitumor agents …

Synthesis and biological evaluation of novel dehydroabietic acid derivatives conjugated with acyl-thiourea peptide moiety as antitumor agents

L Jin, HE Qu, XC Huang, YM Pan, D Liang… - International Journal of …, 2015 - mdpi.com
A series of dehydroabietic acid (DHAA) acyl-thiourea derivatives were designed and
synthesized as potent antitumor agents. The in vitro pharmacological screening results …

Synthesis and cytotoxicity evaluation of dehydroabietic acid derivatives bearing nitrate moiety

F Li, L Huang, X Zhou, Q Li, X Ma, W Duan… - Chinese Journal of …, 2020 - sioc-journal.cn
In order to find more effective antitumor agents, a series of novel dehydroabietic acid
derivatives bearing nitrate moiety were designed and synthesized. Their cytotoxicities were …

Click chemistry-based synthesis and anticancer activity evaluation of novel C-14 1, 2, 3-triazole dehydroabietic acid hybrids

W Hou, Z Luo, G Zhang, D Cao, D Li, H Ruan… - European Journal of …, 2017 - Elsevier
A concise and efficient synthetic approach has been established to readily access a series
of novel C-14 1, 2, 3-triazole-tethered dehydroabietic acid derivatives in moderate to high …

[HTML][HTML] Design, synthesis and evaluation of novel dehydroabietic acid-dithiocarbamate hybrids as potential multi-targeted compounds for tumor cytotoxicity

C Ni, YJ Wu, M Ran, J Li, H Li, C Lan, J Liu… - Arabian Journal of …, 2022 - Elsevier
In the present study, novel representatives of the important group of biologically-active,
dehydroabietic acid-bearing dithiocarbamate moiety, were synthesized and characterized …

Design, synthesis and anticancer activity of new Benzofuran‐Chalcone hybrids and their water soluble sodium salts

S Cinar‐Asa, D Coskun, O Akgun, H Akgun… - …, 2023 - Wiley Online Library
Abstract In this study, firstly, 1‐(7‐ethoxy‐1‐benzofuran‐2‐yl) ethanone and 1, 1'‐(7‐ethoxy‐
1‐benzofuran‐2, 4‐diyl) diethanone were synthesized for the starting reagent purposes. The …