Structural alterations of the 5′ noncoding region of the BCL-6 gene have been found in
40% of diffuse large cell lymphoma (DLCL) and 5% to 10% of follicular lymphomas (FL) …

The BCL-6 gene is frequently involved in translocations occurring at the 3q27 locus and is
rear-ranged in approximately 30% of diffuse large cell lymphomas and in a small fraction of …

The BCL-6 gene is known to be located on chromosome 3q27, at the breakpoint of the 3q27-
associated translocations that occur frequently in human non-Hodgkin's lymphomas (NHLs) …

The proto-oncogene BCL-6 encodes a transcriptional repressor protein that is expressed at
high levels in germinal center B cells and lymphomas with a germinal center B cell …

Genetic alterations of the BCL-6 gene in mice and man have established BCL-6 as a pivotal
regulator of normal differentiation of B and T lymphocytes as well as one of the most …

The bcl-2 gene on chromosome 18 at q21 and the bcl-6 gene on chromosome 3 at q27 are
both highly regulated during B-cell differentiation and show an inverse relationship of …

Many malignancies of mature B cells are characterized by chromosomal translocations
involving the immunoglobulin heavy chain (IGH) locus on chromosome 14q32. 3 and result …

BCL-6, a transcriptional repressor frequently translocated in lymphomas, regulates germinal
center B cell differentiation and inflammation. DNA microarray screening identified genes …

BCL10 is an apoptotic regulatory molecule identified through its direct involvement in t (1;
14)(p22; q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. We examined …

Background Chromosomal aberrations of BCL11A at 2p16. 1 have been reported in a
variety of B-cell malignancies and its deficiency in mice leads to a profound block in B-cell …