The human Ras association domain family 1A gene (RASSF1A), recently cloned from the
lung tumor suppressor locus 3p21. 3, was shown to be hypermethylated in primary lung …

The human Ras association domain family 1A (RASSF1A) gene, recently isolated from the
lung and breast tumor suppressor locus 3p21. 3, is highly methylated in primary lung, breast …

Loss of genetic material from chromosome 3p21. 3 is one of the most common and earliest
events in the pathogenesis of lung cancer and many other solid tumors. The chromosomal …

Homozygous deletion and loss of heterozygosity (LOH) at chromosome 3p21 have been
observed in several types of human cancer including lung cancer and breast cancer. In …

Loss of heterozygosity at 3p21. 3 occurs in more than 90% of small cell lung carcinomas
(SCLCs). The Ras association domain family 1 (RASSF1) gene cloned from the lung tumor …

Recently, we have identified a new putative tumor suppressor gene, RASSF1A (Ras
association domain family 1A gene), located at human chromosome 3p21. 3, the segment …

Recent findings have shown the inactivation of a Ras effector homologue gene referred to
as the Ras association domain family 1 (RASSF1) gene, which is a potential human tumor …

Previously we analysed overlapping homozygous deletions in lung and breast
tumours/tumour lines and defined a small region of 120 kb (part of LCTSGR1) at 3p21. 3 that …

Recently, we have cloned and characterized the Ras association domain family 1A gene
(RASSF1A) at 3p21. 3, from which loss of genetic material is one of the most frequent events …

Methylation‐associated inactivation of RASSF1, a putative tumor suppressor identified at
3p21. 3, is reported in several cancers. We examined RASSF1 in non‐small lung cancer …