Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
LJ Russell, M Capasso, I Vater… - Blood, The Journal …, 2009 - ashpublications.org
We report 2 novel, cryptic chromosomal abnormalities in precursor B-cell acute
lymphoblastic leukemia (BCP-ALL): a translocation, either t (X; 14)(p22; q32) or t (Y; …
lymphoblastic leukemia (BCP-ALL): a translocation, either t (X; 14)(p22; q32) or t (Y; …
Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non–high-risk precursor B-cell acute lymphoblastic leukemia in children treated …
G Cario, M Zimmermann, R Romey… - Blood, The Journal …, 2010 - ashpublications.org
High-level expression of the cytokine receptor-like factor 2 gene, CRLF2, in precursor B-cell
acute lymphoblastic leukemia (pB-ALL) was shown to be caused by a translocation …
acute lymphoblastic leukemia (pB-ALL) was shown to be caused by a translocation …
Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia
SK Tasian, MY Doral, MJ Borowitz… - Blood, The Journal …, 2012 - ashpublications.org
Adults and children with high-risk CRLF2-rearranged acute lymphoblastic leukemia (ALL)
respond poorly to current cytotoxic chemotherapy and suffer unacceptably high rates of …
respond poorly to current cytotoxic chemotherapy and suffer unacceptably high rates of …
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia
A Yoda, Y Yoda, S Chiaretti… - Proceedings of the …, 2010 - National Acad Sciences
The prognosis for adults with precursor B-cell acute lymphoblastic leukemia (B-ALL)
remains poor, in part from a lack of therapeutic targets. We identified the type I cytokine …
remains poor, in part from a lack of therapeutic targets. We identified the type I cytokine …
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor …
RC Harvey, CG Mullighan, IM Chen… - Blood, The Journal …, 2010 - ashpublications.org
Gene expression profiling of 207 uniformly treated children with high-risk B-progenitor acute
lymphoblastic leukemia revealed 29 of 207 cases (14%) with markedly elevated expression …
lymphoblastic leukemia revealed 29 of 207 cases (14%) with markedly elevated expression …
Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemia
CG Mullighan, JR Collins-Underwood, LAA Phillips… - Nature …, 2009 - nature.com
Aneuploidy and translocations are hallmarks of B-progenitor acute lymphoblastic leukemia
(ALL), but many individuals with this cancer lack recurring chromosomal alterations. Here …
(ALL), but many individuals with this cancer lack recurring chromosomal alterations. Here …
Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report …
L Hertzberg, E Vendramini, I Ganmore… - Blood, The Journal …, 2010 - ashpublications.org
We report gene expression and other analyses to elucidate the molecular characteristics of
acute lymphoblastic leukemia (ALL) in children with Down syndrome (DS). We find that by …
acute lymphoblastic leukemia (ALL) in children with Down syndrome (DS). We find that by …
Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial
HM Ensor, C Schwab, LJ Russell… - Blood, The Journal …, 2011 - ashpublications.org
Deregulated expression of CRLF2 (CRLF2-d) arises via its juxtaposition to the IGH@
enhancer or P2RY8 promoter. Among 865 BCP-ALL children treated on MRC ALL97, 52 …
enhancer or P2RY8 promoter. Among 865 BCP-ALL children treated on MRC ALL97, 52 …
Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project
One recently identified subtype of pediatric B-precursor acute lymphoblastic leukemia (ALL)
has been termed BCR-ABL1–like or Ph-like because of similarity of the gene expression …
has been termed BCR-ABL1–like or Ph-like because of similarity of the gene expression …
CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes
C Reindl, H Quentmeier, K Petropoulos, PA Greif… - Clinical Cancer …, 2009 - AACR
Purpose: CBL is a negative regulator of activated receptor tyrosine kinases (RTK). In this
study, we determined the frequency of CBL mutations in acute leukemias and evaluated the …
study, we determined the frequency of CBL mutations in acute leukemias and evaluated the …