The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self‐antigen‐specific immunoglobulin receptors
PA Silveira, E Johnson, HD Chapman… - European journal of …, 2002 - Wiley Online Library
B lymphocytes partially contribute to autoimmune type 1 diabetes (T1D) as a subset of APC
with a preferential ability to trigger pathogenic CD4 T cells. We hypothesized that this …
with a preferential ability to trigger pathogenic CD4 T cells. We hypothesized that this …
The role of B lymphocytes as key antigen-presenting cells in the development of T cell-mediated autoimmune type 1 diabetes
DV Serreze, PA Silveira - Curr Dir Autoimmun, 2003 - books.google.com
The detection in patients with insulin-dependent diabetes mellitus (IDDM) of circulating
antibodies which recognize pancreatic cells provided early evidence that this disease has …
antibodies which recognize pancreatic cells provided early evidence that this disease has …
B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice
DV Serreze, SA Fleming, HD Chapman… - The Journal of …, 1998 - journals.aai.org
Nonobese diabetic (NOD) mice genetically deficient in B lymphocytes (NOD. Igμ null) are
resistant to T cell-mediated autoimmune insulin-dependent diabetes mellitus (IDDM). Ig …
resistant to T cell-mediated autoimmune insulin-dependent diabetes mellitus (IDDM). Ig …
B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new" speed congenic" stock of NOD. Ig mu null mice.
DV Serreze, HD Chapman, DS Varnum… - The Journal of …, 1996 - rupress.org
The T lymphocytes mediating autoimmune destruction of pancreatic beta cells in the
nonobese diabetic (NOD) mouse model of insulin-dependent diabetes mellitus (IDDM) may …
nonobese diabetic (NOD) mouse model of insulin-dependent diabetes mellitus (IDDM) may …
B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic mice
PA Silveira, J Dombrowsky, E Johnson… - The Journal of …, 2004 - journals.aai.org
One mechanism whereby B cells contribute to type 1 diabetes in nonobese diabetic (NOD)
mice is as a subset of APCs that preferentially presents MHC class II-bound pancreatic β cell …
mice is as a subset of APCs that preferentially presents MHC class II-bound pancreatic β cell …
B lymphocyte “original sin” in the bone marrow enhances islet autoreactivity in type 1 diabetes–prone nonobese diabetic mice
RA Henry-Bonami, JM Williams… - The Journal of …, 2013 - journals.aai.org
Effective central tolerance is required to control the large extent of autoreactivity normally
present in the developing B cell repertoire. Insulin-reactive B cells are required for type 1 …
present in the developing B cell repertoire. Insulin-reactive B cells are required for type 1 …
Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions
RT Graser, TP DiLorenzo, F Wang… - The Journal of …, 2000 - journals.aai.org
Previous work has indicated that an important component for the initiation of autoimmune
insulin-dependent diabetes mellitus (IDDM) in the NOD mouse model entails MHC class I …
insulin-dependent diabetes mellitus (IDDM) in the NOD mouse model entails MHC class I …
B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice
M Falcone, J Lee, G Patstone, B Yeung… - The Journal of …, 1998 - journals.aai.org
Recent reports have shown that B cells play a key role in the pathogenesis of T cell-
mediated autoimmune diseases such as insulin-dependent diabetes mellitus (IDDM) in …
mediated autoimmune diseases such as insulin-dependent diabetes mellitus (IDDM) in …
Cutting edge: B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice
C Hulbert, B Riseili, M Rojas… - The Journal of …, 2001 - journals.aai.org
Type I diabetes mellitus (TIDM) is an autoimmune disorder characterized by T cell-mediated
destruction of insulin-producing β cells in the pancreas. In the nonobese diabetic (NOD) …
destruction of insulin-producing β cells in the pancreas. In the nonobese diabetic (NOD) …
Differential contributions of APC subsets to T cell activation in nonobese diabetic mice
AM Marleau, KL Summers, B Singh - The Journal of Immunology, 2008 - journals.aai.org
Despite the pivotal role of dendritic cells (DC) in shaping immunity, little is known about their
functionality in type 1 diabetes. Moreover, due to the paucity of DC in vivo, functional studies …
functionality in type 1 diabetes. Moreover, due to the paucity of DC in vivo, functional studies …