We describe a six-compartment physiological model of the kinetics and dynamics of
induction of anaesthesia with propofol in sheep. It includes a faithful description of initial …

We describe a six-compartment kinetic and dynamic physiological model of induction of
anaesthesia with thiopental. The model included an accurate account of initial drug …

The determinants of induction of anaesthesia with propofol, and their implications for dose
requirements, were analysed using a physiological model of the process, validated …

A marked reduction in the dose of propofol required to achieve the onset of anesthesia with
slower administration rates has previously been reported, but the mechanism of this …

Background: Previous work had shown dysequilibrium between the arterial blood and brain
concentrations of the intravenous anaesthetic agent propofol following its rapid …

Background The disposition of propofol in man is commonly described using a three-
compartment mamillary model. However, these models do not incorporate blood flows as …

The time-course of propofol concentrations in the blood and brain following rapid
administration of three doses were examined using a sheep preparation and regional …

The primary objective of this study was to determine in vivo tissue/blood partition coefficients
of propofol for use in physiological modelling of its pharmacokinetics. The sheep was used …

We have tested a published algorithm for pharmaco-kinetic model controlled infusion of
propofol to supplement 67% nitrous oxide for general anaesthesia in Chinese children aged …

The pharmacokinetics of propofol in a dose of 2.5 mg kg− 1 given via a vein in the
antecubital fossa were studied in 18 patients. Anaesthesia was maintained with nitrous …