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The factors which provide short-term and long-term control of transmitter release - ScienceDirect
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Publisher Summary This chapter discusses facilitation, augmentation, and potentiation of
transmitter release. The effect of repetitive stimulation on transmitter release has been …

have provided evidence that NA inhibits the firing rate in the cerebral cortex. it is suggested
therefore that the release of ACh from the cortex is continuously controlled by NA released …

Neurons send out a multitude of chemical signals, called neurotransmitters, to communicate
between neurons in brain, and between neurons and target cells in the periphery. The most …

Neurotransmitter release does not seem to be regulated by neuronal receptors mediating
feedback and the mechanism of action of presynaptically active agents is still uncertain. In a …

Modulation of neurotransmitter release was formally recognised in the late 1960s when it
was reported that the amount of transmitter released from the neurone was inversely related …

Only limited evidence, much of it repetitious, has supported the hypothesis that transmitter
release is regulated by negative and positive feedback. It is shown here that the theory fails …

Most of the data on which our views of the process of modulation of neurotransmitter release
are based have been obtained from in vitro experimentation. Often somewhat extreme …

Publisher Summary This chapter discusses the reversibility of transmitter release. A variety
of different mechanisms to account for the salient features of transmitter release have been …