Importance Continuous morphine infusion as standard postoperative analgesic therapy in
young infants is associated with unwanted adverse effects such as respiratory depression …

Background The safety and value of acetaminophen (paracetamol) in addition to continuous
morphine infusion has never been studied in newborns and young infants. We investigated …

Objective To determine whether intravenous paracetamol therapy is effective in pain therapy
in premature infants. Study design From June 2009 to December 2011, 108 infants born …

Summary Background and Objectives Perioperative pain in children can be effectively
managed with systemic opioids, but addition of paracetamol or nonsteroidal anti …

A randomized double-blind clinical trial compared the efficacy of 10μg/kg/h morphine
continuous intravenous infusion (CM) with that of 30μg/kg morphine (IM) every 3h after …

Objective To investigate age-related differences in morphine requirements and metabolism
in full-term neonates. Design and setting Randomized double-blind study in the pediatric …

Abstract Background and Objectives From a previously validated paediatric population
pharmacokinetic model, it was derived that non-linear morphine maintenance doses of 5 …

Background: Postoperative pain management in children is often empirical rather than
evidence based. Morphine is the pharmacological treatment most widely used and although …

Objectives We suggested a loading dose (20 mg· kg− 1) followed by 10 mg· kg− 1 q6h of
intravenous (IV) paracetamol to achieve an effect compartment concentration of 11 mg· l− 1 …

Background. To investigate clinical variables such as gestational age, sex, weight, the
therapeutic regimens used and mechanical ventilation that might affect morphine …