Background The neurodegenerative process of Alzheimer's disease (AD) may begin
decades before symptom onset, prompting interest in primary prevention in midlife. Much of …

Abstract Introduction Most Alzheimer's disease (AD) prevention studies focus on older adults
or persons with existing cognitive impairment. This study describes the design and progress …

Background: Research indicates that the neurodegenerative process of Alzheimer's disease
may begin in middle adulthood. Nevertheless, most prevention studies target adults 65+ or …

Background US POINTER is a Phase 3, multicenter, randomized 2‐year clinical trial of two
multidomain lifestyle interventions in 2111 older adults who are at increased risk of cognitive …

Dementia is understood to arise from a mixed etiology, enveloping chronic inflammatory and
vascular impacts on the brain, driven by a constellation of modifiable risk factors which are …

Abstract Background Exercise and Intensive Vascular Risk Reduction in Preventing
Dementia (rrAD Study) was a NIH‐funded multisite, clinical trial. The rrAD Study assesses …

Background There is an urgent need to expand the Finnish Geriatric Intervention Study to
Prevent Cognitive Impairment and Disability (FINGER) results in geographically and …

Objective To quantify the impact of a healthy lifestyle on the risk of Alzheimer dementia.
Methods Using data from the Chicago Health and Aging Project (CHAP; n= 1,845) and the …

Objective To investigate the associations between lifestyle and vascular risk factors and
changes in Alzheimer's disease (AD) biomarkers (beta-amyloid load via 11C-PiB PET …

Objective: While the importance of healthy lifestyles for preventing Alzheimer's disease and
related dementias (ADRD) has been recognized, epidemiologic evidence remains limited …