Myxobacteria are Gram-negative soil-dwelling bacteria belonging to the phylum
Proteobacteria. They are a rich source of promising compounds for clinical application, such …

Three lactones were isolated from the culture medium of the endophytic fungus Xylaria sp.
Grev.(Xylariaceae). The major compound, which showed weak activity (13 μ g/mL) against a …

We have synthesized new derivatives of the macrolide antibiotics erythromycin and
azithromycin. Novel deoxysugar moieties were attached to these standard antibiotics by …

The 16-membered macrolide antibiotics (eg tylosin A and josamycin) are mainly used in
veterinary medicine, and are much less studied than their 14-and 15-membered …

In the course of our screening program to discover antimalarial antibiotics from soil
microorganisms which are active against drug-resistant parasites in vitro and in vivo, we …

From the promising results we previously obtained in quinazoline series and to complete the
evaluation of the in vitro antiplasmodial activity of original 2-trichloromethylquinazolines, we …

Toxoplasmosis, caused by the obligate intracellular parasite Toxoplasma gondii, affects
about one-third of the world's population and can cause severe congenital, neurological and …

Moxalactam was administered intravenously or intramuscularly or both in doses of 1 to 12
g/day to 45 patients with clinically significant infections (17 soft tissue or bone, 9 …

Summary Synopsis: Moxalactam 1 (latamoxef) is a new synthetic oxa-β-lactam antibiotic
administered intravenously or intramuscularly. It has a broad spectrum of activity against …

With the emergence of Plasmodium falciparum infections exhibiting increased parasite
clearance times in response to treatment with artemisinin-based combination therapies, the …