Structural determinants of binding to the μ-opioid receptor, an important target in analgesia,
attract great scientific attention. Many natural and synthetic peptides and peptidomimetics …

Molecular modeling approaches are an indispensable part of the drug design process. They
not only support the process of searching for new ligands of a given receptor, but they also …

A series of conformationally restricted analogs of the cyclic $\mu $ opioid receptor selective
tetrapeptide Tyr-c (D-Cys-Phe-D-Pen) NH $\sb2 $(S-Et-S)(JOM-6) were prepared in order to …

Although the μ opioid receptor (MOR) was pharmacologically and biochemically identified in
binding studies forty years ago, its structure, function, and true complexity only have …

A pair of diastereomeric peptidomimetics based upon opioid receptor-binding
pharmacophore models derived for a series of opioid tetrapeptides was synthesized. Both …

The μ-opioid receptor (MOR) is an important target in the search for novel analgesics. The
recently published crystal structure of MOR gives the possibility of in silico investigations …

Opioid receptors are the principal targets for opioids, which have been used as analgesics
for centuries. Opioid receptors belong to the rhodopsin family of G-protein coupled receptors …

Opioid receptors (OPRs) are important agents in the centeral nervous system (CNS)
function. These receptors belong to “G-Protein Coupled Receptors (GPCRs)” which have …

Opioids are well known for their potent analgesic efficacy and severe side effects. Studies
have shown that analgesic effects are mediated by the downstream G-protein-dependent …

For three-dimensional understanding of the mechanisms that control potency and selectivity
of the ligand binding at the atomic level, we have analysed opioid receptor-ligand interaction …