Territory-wide Chinese cohort of long QT syndrome: random survival forest and Cox analyses

G Tse, S Lee, J Zhou, T Liu, ICK Wong… - Frontiers in …, 2021 - frontiersin.org
Introduction: Congenital long QT syndrome (LQTS) is a cardiac ion channelopathy that
predisposes affected individuals to spontaneous ventricular tachycardia/fibrillation (VT/VF) …

Transethnic genome-wide association study provides insights in the genetic architecture and heritability of long QT syndrome

N Lahrouchi, R Tadros, L Crotti, Y Mizusawa… - Circulation, 2020 - Am Heart Assoc
Background: Long QT syndrome (LQTS) is a rare genetic disorder and a major preventable
cause of sudden cardiac death in the young. A causal rare genetic variant with large effect …

Association of genetic and clinical aspects of congenital long QT syndrome with life-threatening arrhythmias in Japanese patients

W Shimizu, H Makimoto, K Yamagata… - JAMA …, 2019 - jamanetwork.com
Importance Long QT syndrome (LQTS) is caused by several ion channel genes, yet risk of
arrhythmic events is not determined solely by the responsible gene pathogenic variants …

Common genotypes of long QT syndrome in China and the role of ECG prediction

Y Gao, W Liu, C Li, X Qiu, X Qin, B Guo, X Liu, J Li… - Cardiology, 2016 - karger.com
Objectives: Genetic testing, a gold standard for long QT syndrome (LQTS) diagnosis, is time-
consuming and costly when all the 15 candidate genes are screened. Since genotype …

Deep Learning–Augmented ECG Analysis for Screening and Genotype Prediction of Congenital Long QT Syndrome

R Jiang, CC Cheung, M Garcia-Montero… - JAMA …, 2024 - jamanetwork.com
Importance Congenital long QT syndrome (LQTS) is associated with syncope, ventricular
arrhythmias, and sudden death. Half of patients with LQTS have a normal or borderline …

KCNH2 p.Gly262AlafsTer98: A New Threatening Variant Associated with Long QT Syndrome in a Spanish Cohort

R Lorca, A Junco-Vicente, A Pérez-Pérez, I Pascual… - Life, 2022 - mdpi.com
Long QT syndrome (LQTS) is an inherited (autosomal dominant) channelopathy associated
with susceptibility to ventricular arrhythmias due to malfunction of ion channels in …

Follow-up of 316 molecularly defined pediatric long-QT syndrome patients: clinical course, treatments, and side effects

M Koponen, A Marjamaa, A Hiippala… - Circulation …, 2015 - Am Heart Assoc
Background—Inherited long-QT syndrome (LQTS) is associated with risk of sudden death.
We assessed the clinical course and the fulfillment of current treatment strategies in …

Risk prediction in women with congenital long QT syndrome

I Goldenberg, JM Bos, A Yoruk, AY Chen… - Journal of the …, 2021 - Am Heart Assoc
Background We aimed to provide personalized risk estimates for cardiac events (CEs) and
life‐threatening events in women with either type 1 or type 2 long QT. Methods and Results …

Interplay between genetic substrate, QTc duration, and arrhythmia risk in patients with long QT syndrome

A Mazzanti, R Maragna, G Vacanti, N Monteforte… - Journal of the American …, 2018 - jacc.org
Abstract Background: Long QT syndrome (LQTS) is a common inheritable arrhythmogenic
disorder, often secondary to mutations in the KCNQ1, KCNH2, and SCN5A genes. The …

Paediatric/young versus adult patients with long QT syndrome

S Lee, J Zhou, K Jeevaratnam, WT Wong… - Open …, 2021 - openheart.bmj.com
Introduction Long QT syndrome (LQTS) is a less prevalent cardiac ion channelopathy than
Brugada syndrome in Asia. The present study compared the outcomes between …