Territory-wide Chinese cohort of long QT syndrome: random survival forest and Cox analyses
Introduction: Congenital long QT syndrome (LQTS) is a cardiac ion channelopathy that
predisposes affected individuals to spontaneous ventricular tachycardia/fibrillation (VT/VF) …
predisposes affected individuals to spontaneous ventricular tachycardia/fibrillation (VT/VF) …
Transethnic genome-wide association study provides insights in the genetic architecture and heritability of long QT syndrome
N Lahrouchi, R Tadros, L Crotti, Y Mizusawa… - Circulation, 2020 - Am Heart Assoc
Background: Long QT syndrome (LQTS) is a rare genetic disorder and a major preventable
cause of sudden cardiac death in the young. A causal rare genetic variant with large effect …
cause of sudden cardiac death in the young. A causal rare genetic variant with large effect …
Association of genetic and clinical aspects of congenital long QT syndrome with life-threatening arrhythmias in Japanese patients
W Shimizu, H Makimoto, K Yamagata… - JAMA …, 2019 - jamanetwork.com
Importance Long QT syndrome (LQTS) is caused by several ion channel genes, yet risk of
arrhythmic events is not determined solely by the responsible gene pathogenic variants …
arrhythmic events is not determined solely by the responsible gene pathogenic variants …
Common genotypes of long QT syndrome in China and the role of ECG prediction
Y Gao, W Liu, C Li, X Qiu, X Qin, B Guo, X Liu, J Li… - Cardiology, 2016 - karger.com
Objectives: Genetic testing, a gold standard for long QT syndrome (LQTS) diagnosis, is time-
consuming and costly when all the 15 candidate genes are screened. Since genotype …
consuming and costly when all the 15 candidate genes are screened. Since genotype …
Deep Learning–Augmented ECG Analysis for Screening and Genotype Prediction of Congenital Long QT Syndrome
Importance Congenital long QT syndrome (LQTS) is associated with syncope, ventricular
arrhythmias, and sudden death. Half of patients with LQTS have a normal or borderline …
arrhythmias, and sudden death. Half of patients with LQTS have a normal or borderline …
KCNH2 p.Gly262AlafsTer98: A New Threatening Variant Associated with Long QT Syndrome in a Spanish Cohort
R Lorca, A Junco-Vicente, A Pérez-Pérez, I Pascual… - Life, 2022 - mdpi.com
Long QT syndrome (LQTS) is an inherited (autosomal dominant) channelopathy associated
with susceptibility to ventricular arrhythmias due to malfunction of ion channels in …
with susceptibility to ventricular arrhythmias due to malfunction of ion channels in …
Follow-up of 316 molecularly defined pediatric long-QT syndrome patients: clinical course, treatments, and side effects
M Koponen, A Marjamaa, A Hiippala… - Circulation …, 2015 - Am Heart Assoc
Background—Inherited long-QT syndrome (LQTS) is associated with risk of sudden death.
We assessed the clinical course and the fulfillment of current treatment strategies in …
We assessed the clinical course and the fulfillment of current treatment strategies in …
Risk prediction in women with congenital long QT syndrome
I Goldenberg, JM Bos, A Yoruk, AY Chen… - Journal of the …, 2021 - Am Heart Assoc
Background We aimed to provide personalized risk estimates for cardiac events (CEs) and
life‐threatening events in women with either type 1 or type 2 long QT. Methods and Results …
life‐threatening events in women with either type 1 or type 2 long QT. Methods and Results …
Interplay between genetic substrate, QTc duration, and arrhythmia risk in patients with long QT syndrome
Abstract Background: Long QT syndrome (LQTS) is a common inheritable arrhythmogenic
disorder, often secondary to mutations in the KCNQ1, KCNH2, and SCN5A genes. The …
disorder, often secondary to mutations in the KCNQ1, KCNH2, and SCN5A genes. The …
Paediatric/young versus adult patients with long QT syndrome
Introduction Long QT syndrome (LQTS) is a less prevalent cardiac ion channelopathy than
Brugada syndrome in Asia. The present study compared the outcomes between …
Brugada syndrome in Asia. The present study compared the outcomes between …