New Findings What is the central question of this study? This study was designed to
investigate whether the Phox2b‐expressing neurons in the retrotrapezoid nucleus are …

Injection of the neurotoxin saporin–substance P (SSP‐SAP) into the retrotrapezoid nucleus
(RTN) attenuates the central chemoreflex in rats. Here we ask whether these deficits are …

Phox2b-expressing neurons of the retrotrapezoid nucleus (RTN), located in the ventrolateral
brainstem, are sensitive to changes in PCO2/pH, have excitatory projections to the central …

The retrotrapezoid “nucleus”(RTN), located in the rostral ventrolateral medullary reticular
formation, contains a bilateral cluster of∼ 1000 glutamatergic noncatecholaminergic …

Key points Neurons of the retrotrapezoid nucleus (RTN) and medullary serotonin (5‐HT)
neurons are both candidates for central CO2/pH chemoreceptors, but it is not known how …

Central chemoreception is the mechanism by which CO2/pH-sensitive neurons (ie,
chemoreceptors) regulate breathing in response to changes in tissue pH. A region of the …

Central respiratory chemoreceptors sense changes in CO2/H+ and initiate the adjustments
to ventilation required to preserve brain and tissue pH. The cellular nature of the sensors …

The retrotrapezoid nucleus (RTN) is located in the rostral medulla oblongata close to the
ventral surface and consists of a bilateral cluster of glutamatergic neurons that are non …

The retrotrapezoid nucleus contains Phox2b-expressing glutamatergic neurons (RTN-
Phox2b neurons) that regulate breathing in a CO2-dependent manner. Here we use …

The retrotrapezoid nucleus (RTN) contains chemosensitive cells that distribute CO2-
dependent excitatory drive to the respiratory network. This drive facilitates the function of the …