Selective serotonin (5-HT) re-uptake inhibitors (SSRIs) are commonly used in the treatment
of generalized anxiety disorder in Humans. However, because only few animal models …

Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are first-line antidepressants but
require several weeks to elicit their actions. Chronic SSRI treatment induces desensitization …

The brain serotonin (5-hydroxytryptamine; 5-HT) system is a powerful modulator of
emotional processes and a target of medications used in the treatment of psychiatric …

Dysfunctions of the serotonergic system have been implicated in a number of psychiatric
disorders including depression, anxiety and disorders of impulse control. To model these …

Anxiety disorders are the most common psychiatric disorders. Typical medications used to
treat patients are benzodiazepines or antidepressants that target serotonin (5-HT) activity …

Maternal separation is known to induce long-term changes in neuroendocrine and
emotional responsiveness to stress in a large variety of models. We examined an animal …

HT1A receptors play a critical role in the pathophysiology of anxiety and depression as well
as in the mode of action of anxiolytic and antidepressant drugs. Mice with a targeted …

Mutant mice that lack serotonin1A receptors exhibit enhanced anxiety‐related behaviors, a
phenotype that is hypothesized to result from impaired autoinhibitory control of midbrain …

5-HT1A receptor knockout (KO) mice have been described as more anxious in various
anxiety paradigms. Because anxiety is often associated with autonomic changes like …

Clinical studies have suggested the involvement of 5-HT1A receptors in anxiety and
depressive disorders because partial 5-HT1A receptor agonists such as buspirone are …