Transgenic mice have been instrumental in dissecting the role of various neuronal proteins
under both physiological and pathological conditions. Pronuclear injection is the most …

Advances in genetics and transgenic approaches have a continuous impact on our
understanding of Alzheimer's disease (AD) and related disorders, especially as aspects of …

Transgenic mice expressing in brain different mutant forms of the Amyloid Precursor Protein,
develop functional, cognitive and pathological defects which resemble or are reminiscent of …

Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several
neurodegenerative diseases, including Alzheimer's disease. In the disease process …

To examine the normal cellular function of tau and its role in pathogenesis, we have created
transgenic mice that overexpress a tau transgene derived from a human PAC that contains …

Background Organotypic brain slice cultures represent an excellent compromise between
single cell cultures and complete animal studies, in this way replacing and reducing the …

In Alzheimer's disease (AD), the microtubule-associated protein, tau, is compromised in its
normal association with microtubules and forms into paired helical filaments (PHF) that are …

The aim of this study was to isolate cis-acting regulatory elements for the generation of
transgenic zebrafish models of neurodegeneration. Zebrafish enolase-2 (eno2) showed …

The first tau transgenic mouse model was established more than a decade ago. Since then,
much has been learned about the role of tau in Alzheimer's disease and related disorders …

Formation of new neurons in the adult brain takes place in the subventricular zone and in
the subgranule layer of the dentate gyrus throughout life. Neurogenesis is thought to play a …