A growing body of evidence suggests that secretion and assembly of insulin to amyloid
fibrils reduce its efficacy in treating type II diabetes and may lead to dysfunctioning of several …

In type 2 diabetes mellitus (T2DM), misfolded human islet amyloid polypeptide (hIAPP)
forms amyloid deposits in pancreatic islets. These amyloid deposits contribute to the …

Amyloidosis is a heterogeneous group of protein deposition diseases associated with the
presence of amyloid fibrils in tissues. Analogs of insulin that are used for treating diabetic …

Protein misfolding and aggregation lead to amyloid generation that in turn may induce cell
membrane disruption and leads to cell apoptosis. In an effort to prevent or treat …

Many metabolic and neurodegenerative diseases are associated with protein misfolding
and aggregation. Insulin a key hormone, under certain conditions aggregates and forms …

Deposition of proteins is a key pathogenic feature of more than 20 amyloid-related diseases.
Inhibiting or reversing amyloid aggregation via the use of small molecules is proposed as …

Amyloid fibrils are associated with more than 20 diseases, including Alzheimer's disease
and type II diabetes. Insulin is a 51-residue polypeptide hormone, with its two polypeptide …

The objective was to investigate the mechanism of the protective effect of silibinin on
amylin/Aβ 1− 42-induced INS-1 cell apoptosis, with special reference to the roles of …

Silybin is a flavonoid lignin compound consisting of two diastereomers with nearly equal
molar ratios. It has been reported that silybin can effectively inhibit the aggregation of …

Amyloid fibrillation of proteins is likely a key factor leading to the development of amyloidosis-
associated diseases. Inhibiting amyloid fibrillation has become a crucial therapeutic …