Finite-element analysis of the adhesion-cytoskeleton-nucleus mechanotransduction pathway during endothelial cell rounding: axisymmetric model
RP Jean, CS Chen, AA Spector - 2005 - asmedigitalcollection.asme.org
Endothelial cells possess a mechanical network connecting adhesions on the basal surface,
the cytoskeleton, and the nucleus. Transmission of force at adhesions via this pathway can …
the cytoskeleton, and the nucleus. Transmission of force at adhesions via this pathway can …
Characterization of the nuclear deformation caused by changes in endothelial cell shape
RP Jean, DS Gray, AA Spector… - J. Biomech …, 2004 - asmedigitalcollection.asme.org
We investigated the mechanotransduction pathway in endothelial cells between their
nucleus and adhesions to the extracellular matrix. First, we measured nuclear deformations …
nucleus and adhesions to the extracellular matrix. First, we measured nuclear deformations …
Contribution of the nucleus to the mechanical properties of endothelial cells
N Caille, O Thoumine, Y Tardy, JJ Meister - Journal of biomechanics, 2002 - Elsevier
The cell nucleus plays a central role in the response of the endothelium to mechanical
forces, possibly by deforming during cellular adaptation. The goal of this work was to …
forces, possibly by deforming during cellular adaptation. The goal of this work was to …
[HTML][HTML] Spatial coordination between cell and nuclear shape within micropatterned endothelial cells
Growing evidence suggests that cytoplasmic actin filaments are essential factors in the
modulation of nuclear shape and function. However, the mechanistic understanding of the …
modulation of nuclear shape and function. However, the mechanistic understanding of the …
[HTML][HTML] A chemomechanical model for nuclear morphology and stresses during cell transendothelial migration
It is now evident that the cell nucleus undergoes dramatic shape changes during important
cellular processes such as cell transmigration through extracellular matrix and endothelium …
cellular processes such as cell transmigration through extracellular matrix and endothelium …
In situ investigation of interrelationships between morphology and biomechanics of endothelial and glial cells and their nuclei
G Rosso, I Liashkovich, V Shahin - Advanced Science, 2019 - Wiley Online Library
Morphology and biomechanics of cells and nuclei are interlinked with one another and play
key roles in fundamental physiological processes. While powerful approaches are available …
key roles in fundamental physiological processes. While powerful approaches are available …
Measurement and finite element modeling of the force balance in the vertical section of adhering vascular endothelial cells
S Deguchi, H Fukamachi, K Hashimoto, K Iio… - Journal of the …, 2009 - Elsevier
Previous studies on the intracellular force balance that forms the adherent cell structure
have paid much attention to the mechanical behavior of cells seen in the horizontal project …
have paid much attention to the mechanical behavior of cells seen in the horizontal project …
[HTML][HTML] A predictive model of cell traction forces based on cell geometry
Recent work has indicated that the shape and size of a cell can influence how a cell
spreads, develops focal adhesions, and exerts forces on the substrate. However, it is …
spreads, develops focal adhesions, and exerts forces on the substrate. However, it is …
Tumor cell nuclei soften during transendothelial migration
During cancer metastasis, tumor cells undergo significant deformation in order to traverse
through endothelial cell junctions in the walls of blood vessels. As cells pass through narrow …
through endothelial cell junctions in the walls of blood vessels. As cells pass through narrow …
Mechanical model of cytoskeleton structuration during cell adhesion and spreading
B Maurin, P Cañadas, H Baudriller, P Montcourrier… - Journal of …, 2008 - Elsevier
The biomechanical behavior of an adherent cell is intimately dependent on its cytoskeleton
structure. Several models have been proposed to study this structure taking into account its …
structure. Several models have been proposed to study this structure taking into account its …
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