Endothelial cells possess a mechanical network connecting adhesions on the basal surface,
the cytoskeleton, and the nucleus. Transmission of force at adhesions via this pathway can …

We investigated the mechanotransduction pathway in endothelial cells between their
nucleus and adhesions to the extracellular matrix. First, we measured nuclear deformations …

The cell nucleus plays a central role in the response of the endothelium to mechanical
forces, possibly by deforming during cellular adaptation. The goal of this work was to …

Growing evidence suggests that cytoplasmic actin filaments are essential factors in the
modulation of nuclear shape and function. However, the mechanistic understanding of the …

It is now evident that the cell nucleus undergoes dramatic shape changes during important
cellular processes such as cell transmigration through extracellular matrix and endothelium …

Morphology and biomechanics of cells and nuclei are interlinked with one another and play
key roles in fundamental physiological processes. While powerful approaches are available …

Previous studies on the intracellular force balance that forms the adherent cell structure
have paid much attention to the mechanical behavior of cells seen in the horizontal project …

Recent work has indicated that the shape and size of a cell can influence how a cell
spreads, develops focal adhesions, and exerts forces on the substrate. However, it is …

During cancer metastasis, tumor cells undergo significant deformation in order to traverse
through endothelial cell junctions in the walls of blood vessels. As cells pass through narrow …

The biomechanical behavior of an adherent cell is intimately dependent on its cytoskeleton
structure. Several models have been proposed to study this structure taking into account its …