ABSTRACT Interleukin 12 (IL‐12) is a crucial cytokine in the regulation of T helper 1 vs. T
helper 2 immune responses. In the present study, we investigated the effect of the …

Adenosine (ADO) exerts potent anti-inflammatory and immunosuppressive effects. In this
paper we address the possibility that these effects are partly mediated by inhibition of the …

Adenosine, acting at its receptors, particularly A 2A receptors, is a potent endogenous anti-
inflammatory agent that modulates the functions and differentiation of inflammatory and …

Adenosine receptor ligands have anti-inflammatory effects and modulate immune responses
by up-regulating IL-10 production by immunostimulated macrophages. The adenosine …

Adenosine is an endogenous nucleoside that regulates many physiological processes
through the activation of its four receptors: A1, A2A, A2B and A3. Previous studies have …

Adenosine is a potent endogenous antiinflammatory agent released by cells under
metabolically unfavorable conditions. Its effects on the production of IL-10 by human …

Objective. The acute antiinflammatory effects of methotrexate are mediated, at least in part,
by increased extracellular adenosine concentrations at inflamed sites. This observation …

Adenosine, a purine nucleoside generated by the dephosphorylation of adenine
nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many …

Adenosine agonists inhibit TNF-alpha production in macrophage and monocytes, but the
mechanism is unknown. Therefore, we studied the human macrophage cell line U937 to …

Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …