In epigenome-wide association studies (EWAS), different methylation profiles of distinct cell
types may lead to false discoveries. We introduce ReFACTor, a method based on principal …

In epigenome-wide association studies, cell-type composition often differs between cases
and controls, yielding associations that simply tag cell type rather than reveal fundamental …

It is well recognized that cell-type heterogeneity hampers the interpretation of Epigenome-
Wide Association Studies (EWAS). Many tools have emerged to address this issue …

Epigenome-wide association studies (EWAS) hold promise for the detection of new
regulatory mechanisms that may be susceptible to modification by environmental and …

It is important for large-scale epigenomic studies to determine and explore the nature of
hidden confounding variation, most importantly cell composition. We developed MeDeCom …

A major challenge faced by epigenome-wide association studies (EWAS) is cell-type
heterogeneity. As many EWAS have already demonstrated, adjusting for changes in cell …

Background Epigenome-wide association studies of human disease and other quantitative
traits are becoming increasingly common. A series of papers reporting age-related changes …

An outstanding challenge of epigenome-wide association studies (EWASs) performed in
complex tissues is the identification of the specific cell type (s) responsible for the observed …

Epigenome‐wide association studies (EWAS) are designed to characterise population‐level
epigenetic differences across the genome and link them to disease. Most commonly, they …

Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …