BACKGROUND: Bile salts have been shown to modulate gastrointestinal epithelial
restitution, differentiation, and other functions. Prior studies have shown that the bile salt …

Background Mucosal restitution is an important repair modality in the gastrointestinal tract.
We have shown that taurodeoxycholate increases intestinal epithelial cell migration by …

BACKGROUND: Bile salts increase intestinal mucosal proliferation through an increase in c-
Myc, a transcription factor that controls the expression of numerous translation regulatory …

Background: Despite the clear demonstration that an increase in faecal bile salt
concentration can augment colonocyte proliferation, it is still controversial whether bile salts …

We hypothesized that the NF-κB pathway would be operative in the proliferative effect of bile
salts on enterocytes. To determine this, we studied the effect of the bile salt …

Background. In addition to aiding in the digestion of fats, luminal bile salts have been shown
to modulate gastrointestinal epithelial growth, differentiation, and other functions. We …

Bile acids have been implicated as tumor promoters that enhance epithelial proliferation and
the development of colonic tumors. This study investigated the effects of bile acids on the …

Apoptosis plays a critical role in intestinal mucosal homeostasis. We previously showed that
the bile salt taurodeoxycholate has a beneficial effect on the intestinal mucosa through an …

AIM: To investigate the effect of six bile salts: glycocholate (GC), glycochenodeoxycholate
(GCDC), glycodeoxycholate (GDC), taurocholate (TC), taurochenodeoxycholate (TCDC) …

PURPOSE: In vitro supplementation of the bile salt, taurodeoxycholic acid (TDCA), has been
shown to stimulate proliferation and prevent intestinal apoptosis in IEC-6 cells. We …