Abstract The Anaphase Promoting Complex (APC) coactivator Cdh1 drives proper cell cycle
progression and is implicated in the suppression of tumorigenesis. However, it remains …

Deregulation of the G1/G0 phase of the cell cycle can lead to cancer. During G1, most cells
commit alternatively to DNA replication and division, or to cell-cycle exit and differentiation …

To sustain genomic stability by correct DNA replication and mitosis, cell cycle progression is
tightly controlled by the cyclic activity of cyclin-dependent kinases, their binding to cyclins in …

Cdh1, a coactivator of the anaphase-promoting complex (APC), is a potential tumor
suppressor. Cdh1 ablation promotes precocious S-phase entry, but it was unclear how this …

Cdh1: a master G0/G1 regulator | Nature Cell Biology Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Periodic activity of the anaphase-promoting complex (APC) ubiquitin ligase determines
progression through multiple cell cycle transitions by targeting cell cycle regulators for …

The anaphase promoting complex/cyclosome (APC/C), is an evolutionarily conserved
protein complex essential for cellular division due to its role in regulating the mitotic …

Dysregulation of the ubiquitin‐proteasome system (UPS) has been implicated in several
types of tumorigenesis. Our previous studies have shown the potential role of Cdh1/APC in …

Triple-negative breast cancer (TNBC) is a type of breast tumor that currently lacks options for
targeted therapy. Tremendous effort has been made to identify treatment targets for TNBC …

Ensuring precise DNA replication and chromosome segregation is essential during cell
division in order to provide genomic stability and avoid malignant growth. Proteolytic control …