Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain
Neuropathic pain results from nerve injuries that cause ectopic firing and increased
nociceptive signal transmission due to activation of key membrane receptors and channels …
nociceptive signal transmission due to activation of key membrane receptors and channels …
Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury
Effective treatment of high-impact pain patients is one of the major stated goals of the
National Pain Strategy in the United States. Identification of new targets and mechanisms …
National Pain Strategy in the United States. Identification of new targets and mechanisms …
Phosphorylated CRMP2 regulates spinal nociceptive neurotransmission
The collapsin response mediator protein 2 (CRMP2) has emerged as a central node in
assembling nociceptive signaling complexes involving voltage-gated ion channels …
assembling nociceptive signaling complexes involving voltage-gated ion channels …
Conditional knockout of CRMP2 in neurons, but not astrocytes, disrupts spinal nociceptive neurotransmission to control the initiation and maintenance of chronic …
Mechanistic studies principally focusing on primary afferent nociceptive neurons uncovered
the upregulation of collapsin response mediator protein 2 (CRMP2)—a dual trafficking …
the upregulation of collapsin response mediator protein 2 (CRMP2)—a dual trafficking …
Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain
A Schmidtko, W Gao, M Sausbier… - Journal of …, 2008 - Soc Neuroscience
The cGMP/cGMP-dependent protein kinase I (cGKI) signaling pathway plays an important
role in spinal nociceptive processing. However, downstream targets of cGKI in this context …
role in spinal nociceptive processing. However, downstream targets of cGKI in this context …
CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain
Neuropathic pain represents a significant and mounting burden on patients and society at
large. Management of neuropathic pain, however, is both intricate and challenging …
large. Management of neuropathic pain, however, is both intricate and challenging …
Dissecting the role of the CRMP2–neurofibromin complex on pain behaviors
A Moutal, Y Wang, X Yang, Y Ji, S Luo, A Dorame… - Pain, 2017 - journals.lww.com
Abstract Neurofibromatosis type 1 (NF1), a genetic disorder linked to inactivating mutations
or a homozygous deletion of the Nf1 gene, is characterized by tumorigenesis, cognitive …
or a homozygous deletion of the Nf1 gene, is characterized by tumorigenesis, cognitive …
Studies on CRMP2 SUMOylation–deficient transgenic mice identify sex-specific Nav1. 7 regulation in the pathogenesis of chronic neuropathic pain
The sodium channel Na v 1.7 is a master regulator of nociceptive input into the central
nervous system. Mutations in this channel can result in painful conditions and produce …
nervous system. Mutations in this channel can result in painful conditions and produce …
Blocking CRMP2 SUMOylation reverses neuropathic pain
A Moutal, ET Dustrude, TM Largent-Milnes… - Molecular …, 2018 - nature.com
Collapsin response mediator proteins 1− 5 (CRMPs1− 5) are a family of cytosolic proteins
that coordinate neuronal migration, axonal guidance, dendritic organization, dendritic spine …
that coordinate neuronal migration, axonal guidance, dendritic organization, dendritic spine …
MBD1 contributes to the genesis of acute pain and neuropathic pain by epigenetic silencing of Oprm1 and Kcna2 genes in primary sensory neurons
The transmission of normal sensory and/or acute noxious information requires intact
expression of pain-associated genes within the pain pathways of nervous system …
expression of pain-associated genes within the pain pathways of nervous system …