Under calorie restriction (CR) animals need to lower energy demands. Whether this involves
a reduction in cellular metabolism is an issue of contention. We exposed C57BL/6 mice to …

Faced with reduced levels of food, animals must adjust to the consequences of the shortfall
in energy. We explored how C57BL/6 mice withdrew energy from different body tissues …

Calorie restriction (CR) delays the onset of age-related disease and extends lifespan in a
number of species. When faced with reduced energy supply animals need to lower energy …

A commonly observed response in mammals to calorie restriction (CR) is reduced body
temperature (T b). We explored how the T b of male C57BL/6 mice responded to graded CR …

Limiting food intake attenuates many of the deleterious effects of aging, impacting upon
healthspan and leading to an increased lifespan. Whether it is the overall restriction of …

Caloric restriction (CR) extends healthy lifespan in many organisms. DBA/2 mice, unlike
C57BL/6 mice, are reported to be unresponsive to CR. To investigate potential differences …

Calorie restriction (CR) typically promotes a reduction in body mass, which correlates with
increased lifespan. We evaluated the overall changes in survival, body mass dynamics, and …

Caloric restriction (CR), the consumption of fewer calories while avoiding malnutrition,
decelerates the rate of aging and the development of age-related diseases. CR has been …

Background Caloric restriction (CR) has long been recognized as a dietary therapy that
improves health and increases longevity. Little is known about the persistent effects of CR …

Late onset, short-term moderate caloric restriction (CR) may have beneficial health effects. A
26% CR regime induced at 14 months of age for 70 days in male C57Bl/6 (ICRFa) mice …