Tumor acidosis promotes disease progression through a stimulation of fatty acid (FA)
metabolism in cancer cells. Instead of blocking the use of FAs by acidic cancer cells, we …

Ferroptosis is an iron-dependent regulated necrosis mediated by lipid peroxidation. Cancer
cells survive under metabolic stress conditions by altering lipid metabolism, which may alter …

Polyunsaturated fatty acids (PUFAs) have been shown to inhibit both normal and tumor cell
growth in vitro. As PUFAs are known to induce a respiratory burst and free radical …

Purpose Ferroptosis is a form of regulated cell death that has the potential to be targeted as
a cancer therapeutic strategy. But cancer cells have a wide range of sensitivities to …

Ferroptosis is associated with lipid hydroperoxides generated by the oxidation of
polyunsaturated acyl chains. Lipid hydroperoxides are reduced by glutathione peroxidase 4 …

Background: Short-chain fatty acids (SCFA) are undergoing increased scrutiny as
chemotherapeutics for colon cancer, although a comprehensive understanding of their …

Polyunsaturated fatty acids (PUFAs), reported to be cytotoxic at micromolar concentrations
for cancer cells in vitroand in vivo, are currently being tested in clinical trials as anti‐cancer …

Exposure of tumor cells to ionizing radiation (IR) alters the microenvironment, particularly the
fatty acid (FA) profile and activity. Moreover, abnormal FA metabolism, either catabolism or …

Cancer cells undergo metabolic reprogramming such as enhanced aerobic glycolysis,
mutations in the tricarboxylic acid cycle enzymes, and upregulation of de novo lipid …

Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …