Premature ovarian failure is a major cause of female infertility. The genetic causes of this
disorder remain unknown in most patients. Using whole-exome sequence analysis of a …

Oligo-and azoospermia are severe forms of male infertility. However, known genetic factors
account only for a small fraction of the cases. Recently, whole-exome sequencing in a large …

Primary ovarian insufficiency (POI) affects~ 1–3, 7% of women under forty and is a public
health problem. Most causes are unknown, but an increasing number of genetic causes …

Aneuploidy often results from chromosome misalignment at metaphases. Oocytes from
senescence-accelerated mice (SAM) exhibit increased chromosome misalignment with age …

To ensure correct meiotic chromosome segregation, sister chromatid cohesion (SCC) needs
to be maintained from its establishment in prophase I oocytes before birth until continuation …

Aneuploidy in fetal chromosomes is one of the causes of pregnancy loss and of congenital
birth defects. It is known that the frequency of oocyte aneuploidy increases with the human …

BACKGROUND Sister chromatid cohesion is essential for ordered chromosome segregation
at mitosis and meiosis. This is carried out by cohesin complexes, comprising four proteins …

Cohesins are important for chromosome structure and chromosome segregation during
mitosis and meiosis. Cohesins are composed of two structural maintenance of …

Sister chromatid cohesion depends on cohesin, a tripartite complex that forms ring structures
to hold sister chromatids together in mitosis and meiosis. Meiocytes feature a multiplicity of …

Cohesin is a protein complex originally identified for its role in sister chromatid cohesion,
although increasing evidence portrays it also as a major organizer of interphase chromatin …