A new synthesis of fully phosphorylated flavones as potent pancreatic cholesterol esterase inhibitors
G Peng, Y Du, Y Wei, J Tang, AY Peng… - Organic & Biomolecular …, 2011 - pubs.rsc.org
Five flavones possessing one to four phenolic groups were fully phosphorylated efficiently
and the obtained compounds showed excellent pancreatic cholesterol esterase (CEase) …
and the obtained compounds showed excellent pancreatic cholesterol esterase (CEase) …
Synthesis and biological evaluation of phosphorylated flavonoids as potent and selective inhibitors of cholesterol esterase
Y Wei, AY Peng, B Wang, L Ma, G Peng, Y Du… - European Journal of …, 2014 - Elsevier
A series of phosphorylated flavonoids were synthesized and investigated in vitro as
inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE). The …
inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE). The …
Inhibition of porcine liver carboxylesterase by phosphorylated flavonoids
We have recently synthesized a series of phosphorylated flavonoids and identified some of
them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity …
them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity …
Phosphaisocoumarins as a new class of potent inhibitors for pancreatic cholesterol esterase
B Li, B Zhou, H Lu, L Ma, AY Peng - European journal of medicinal …, 2010 - Elsevier
Due to the importance of pancreatic cholesterol esterase (CEase) as a potential target in
atherosclerosis and for the development of hypocholesterolemic agents, there are …
atherosclerosis and for the development of hypocholesterolemic agents, there are …
Benzoflavones as cholesterol esterase inhibitors: Synthesis, biological evaluation and docking studies
Abstract A library of forty 7, 8-benzoflavone derivatives was synthesized and evaluated for
their inhibitory potential against cholesterol esterase (CEase). Among all the synthesized …
their inhibitory potential against cholesterol esterase (CEase). Among all the synthesized …
New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds
We present a new class of inhibitors of pancreatic cholesterol esterase (CEase) based on
'priviledged'5-benzylidenerhodanine and 5-benzylidene-2, 4-thiazolidinedione structural …
'priviledged'5-benzylidenerhodanine and 5-benzylidene-2, 4-thiazolidinedione structural …
Isocoumarin-based inhibitors of pancreatic cholesterol esterase
JJ Heynekamp, LA Hunsaker, TA Vander Jagt… - Bioorganic & medicinal …, 2008 - Elsevier
Pancreatic cholesterol esterase (CEase), which is secreted from the exocrine pancreas, is a
serine hydrolase that aids in the bile salt-dependent hydrolysis of dietary cholesteryl esters …
serine hydrolase that aids in the bile salt-dependent hydrolysis of dietary cholesteryl esters …
Synthesis and evaluation of a new series of tri‐, di‐, and mono‐N‐alkylcarbamylphloroglucinols as conformationally constrained inhibitors of cholesterol esterase
MC Lin, GZ Lin, CI Hwang, SY Jian, J Lin… - Protein …, 2012 - Wiley Online Library
Tri‐N‐alkylcarbamylphloroglucinols (1–4) are synthesized as conformationally constrained
analogs of triacylglycerols (TGs) to probe Jenck's proximity effect in the cholesterol esterase …
analogs of triacylglycerols (TGs) to probe Jenck's proximity effect in the cholesterol esterase …
Isolation, characterization and biological activities of novel triprenyl phenols as pancreatic cholesterol esterase inhibitors produced by Stachybotrys sp. F-1839
K Sakai, K Watanabe, K Masuda, M Tsuji… - The Journal of …, 1995 - jstage.jst.go.jp
Tentriprenyl phenol metabolites were isolated as inhibitors of pancreatic cholesterol
esterase from cultures of Stachybotrys sp. F-1839 by solvent extraction and …
esterase from cultures of Stachybotrys sp. F-1839 by solvent extraction and …
Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase
GC Muscia, S Hautmann, GY Buldain, SE Asís… - Bioorganic & Medicinal …, 2014 - Elsevier
Abstract A series of 2-(substituted) phenyl and 2-indolyl quinoline derivatives (10a–l) was
synthesized by an efficient microwave-assisted, trifluoroacetic acid-catalyzed, solvent-free …
synthesized by an efficient microwave-assisted, trifluoroacetic acid-catalyzed, solvent-free …