ABSTRACT A screening of more than 1,500 drug-resistant strains of Mycobacterium
tuberculosis revealed evolutionary patterns characteristic of positive selection for three …

D-Cycloserine is an effective second-line drug against Mycobacterium avium and
Mycobacterium tuberculosis. To analyze the genetic determinants of D-cycloserine …

Introduction: Tuberculosis remains a formidable threat to global public health. Multidrug-
resistant tuberculosis presents increasing burden on the control strategy. D-Cycloserine …

Objectives d-Cycloserine is an important second-line drug used to treat MDR-and XDR-TB.
However, the mechanisms of resistance to d-cycloserine are not well understood. Here we …

A more complete understanding of the genetic basis of drug resistance in Mycobacterium
tuberculosis is critical for prompt diagnosis and optimal treatment, particularly for toxic …

Alanine racemase (Alr) is an essential enzyme in most bacteria; however, some species (eg
Listeria monocytogenes) can utilize d-amino acid transaminase (Dat) to generate d-alanine …

There is a pressing need to develop novel anti-tubercular drugs. High-throughput
phenotypic screening yields chemical series that inhibit bacterial growth. Target …

The primary theme emerging from molecular genetic work conducted with Mycobacterium
tuberculosis and several other mycobacterial species is that resistance is commonly …

ABSTRACT d-Cycloserine (DCS) targets the peptidoglycan biosynthetic enzymes d-alanine
racemase (Alr) and d-alanine: d-alanine ligase (Ddl). Previously, we demonstrated that the …

To characterize mechanisms of resistance to fluoroquinolones by Mycobacterium
tuberculosis, mutants of strain H37Ra were selected in vitro with ofloxacin. Their quinolone …