Myostatin is an extracellular cytokine mostly expressed in skeletal muscles and known to
play a crucial role in the negative regulation of muscle mass. Upon the binding to activin …

Inflammatory cytokine IL‐6 is necessary for the development and progression of cancer
cachexia in the ApcMin/+ mouse, a model of colorectal cancer and cachexia. The purpose of …

One of hallmarks of cachexia is skeletal muscle wasting caused by an imbalance between
the rates of protein synthesis and degradation. Circulating IL‐6 is chronically elevated in …

Recent advances in our understanding of the biology of muscle, and how anabolic and
catabolic stimuli interact to control muscle mass and function, have led to new interest in the …

Cancer cachexia is a debilitating metabolic disorder characterized by loss of body weight,
muscle mass, and functional deterioration that negatively affects patient's quality of life …

Rational. In chronic disorders such as COPD cachexic loss of muscle mass is often seen.
The link between chronic disorders and cachexia has been heavy researched and …

Background Cachexia involves unintentional body weight loss including diminished muscle
and adipose tissue mass and is associated with an underlying disease. Systemic …

Introduction Loss of body weight and involuntary muscle wasting (cachexia) is associated
with many terminal diseases, including heart failure, cancer, COPD and liver cirrhosis. One …

Humoral and tumoral factors collectively promote cancer-induced skeletal muscle wasting
by increasing protein degradation. Although several humoral proteins, namely TNFα (tumour …