[HTML][HTML] Bordetella pertussis strains with increased toxin production associated with pertussis resurgence

FR Mooi, IHM Van Loo, M Van Gent, Q He… - Emerging infectious …, 2009 - ncbi.nlm.nih.gov
Before childhood vaccination was introduced in the 1940s, pertussis was a major cause of
infant death worldwide. Widespread vaccination of children succeeded in reducing illness …

Adaptation of Bordetella pertussis to vaccination: a cause for its reemergence?

FR Mooi, IH Van Loo, AJ King - Emerging infectious diseases, 2001 - ncbi.nlm.nih.gov
In the Netherlands, as in many other western countries, pertussis vaccines have been used
extensively for more than 40 years. Therefore, it is conceivable that vaccine-induced …

Bordetella pertussis and vaccination: the persistence of a genetically monomorphic pathogen

FR Mooi - Infection, Genetics and Evolution, 2010 - Elsevier
Before childhood vaccination was introduced in the 1950s, pertussis or whooping cough
was a major cause of infant death worldwide. Widespread vaccination of children was …

Variation in the Bordetella pertussis Virulence Factors Pertussis Toxin and Pertactin in Vaccine Strains and Clinical Isolates in Finland

FR Mooi, Q He, H van Oirschot… - Infection and immunity, 1999 - Am Soc Microbiol
There is evidence that pertussis is reemerging in vaccinated populations. We have
proposed, and provided evidence for, one explanation for this phenomenon in The …

Small Mutations in Bordetella pertussis Are Associated with Selective Sweeps

M van Gent, MJ Bart, HGJ van der Heide… - 2012 - journals.plos.org
Bordetella pertussis is the causative agent of pertussis, a highly contagious disease of the
human respiratory tract. Despite high vaccination coverage, pertussis has resurged and has …

Global population structure and evolution of Bordetella pertussis and their relationship with vaccination

MJ Bart, SR Harris, A Advani, Y Arakawa, D Bottero… - MBio, 2014 - Am Soc Microbiol
Bordetella pertussis causes pertussis, a respiratory disease that is most severe for infants.
Vaccination was introduced in the 1950s, and in recent years, a resurgence of disease was …

Bordetella pertussis strain variation and evolution postvaccination

T Kallonen, Q He - Expert review of vaccines, 2009 - Taylor & Francis
Bordetella pertussis is a Gram-negative bacterium that causes pertussis or whooping cough
in humans. The incidence of pertussis has increased in young infants, adolescents and …

Strain Variation among Bordetella pertussis Isolates in Finland, Where the Whole-Cell Pertussis Vaccine Has Been Used for 50 Years

A Elomaa, A Advani, D Donnelly, M Antila… - Journal of Clinical …, 2005 - Am Soc Microbiol
Pertussis is an infectious disease of the respiratory tract caused by Bordetella pertussis.
Despite the introduction of mass vaccination against pertussis in Finland in 1952, pertussis …

Analysis of Bordetella pertussis Populations in European Countries with Different Vaccination Policies

SCM Van Amersfoorth, LM Schouls… - Journal of clinical …, 2005 - Am Soc Microbiol
Despite the widespread use of pertussis vaccines during the last decades, pertussis has
remained an endemic disease with frequent epidemic outbreaks. Currently two types of …

Pertussis pathogenesis—what we know and what we don't know

EL Hewlett, DL Burns, PA Cotter… - The Journal of …, 2014 - academic.oup.com
Pertussis is a worldwide public health threat. Bordetella pertussis produces multiple
virulence factors that have been studied individually, and many have recently been found to …